Yazdandoust Shima, Parizadeh Seyyed Mohammad Reza, Moohebati Mohsen, Yaghmaei Parichehreh, Rahsepar Amir Ali, Tavallaie Shima, Soukhtanloo Mohammad, Khojasteh Roshanak, Paydar Roghayeh, Fazlinezhad Afsoon, Falsoleiman Homa, Dehghani Mashalla, Ghayour-Mobarhan Majid, Ferns Gordon A
Department of Biology, Faculty of Basic Sciences, Science Research Campus of Islamic Azad University, Tehran, Iran.
Lipids. 2012 Oct;47(10):963-72. doi: 10.1007/s11745-012-3706-x. Epub 2012 Aug 18.
Serum small dense low-density lipoprotein (sd-LDL) concentrations were measured in patients with angiographically defined coronary artery disease (CAD) and compared to concentrations in healthy subjects. Five hundred and seventy patients with stable CAD were divided into CAD- and CAD+ based on angiography. Patients in whom stenosis was <50 % in diameter were classified as having a 'normal' angiogram (CAD-), otherwise the patients were allocated to the CAD+ group. The CAD+ group was further subcategorized into single-, double- and triple-vessel disease (VD). Serum sd-LDL concentrations were significantly lower in controls compared with CAD+ and CAD- patients (P < 0.001). Moreover, CAD+ patients had higher concentrations of sd-LDL than CAD- patients (P < 0.01). sd-LDL levels were not significantly associated with severity of CAD defined by the number of stenosed coronary arteries (P = 0.245). All participants were also categorized into subgroups with or without metabolic syndrome. Subjects with metabolic syndrome had higher levels of sd-LDL than subjects without metabolic syndrome (P < 0.01). Multiple linear regressions showed that in CAD patients, triacylglycerol, total-cholesterol, body mass index, and waist circumferences were the most important determinants of serum sd-LDL concentrations. We found that sd-LDL levels were significantly higher in patients presenting with symptoms of CAD. Moreover, patients with significant stenosis of their coronary arteries (>50 % stenosis) had higher levels of sd-LDL compared to patients without significant lesions.
对经血管造影确诊为冠心病（CAD）的患者测定血清小而密低密度脂蛋白（sd-LDL）浓度，并与健康受试者的浓度进行比较。570例稳定型CAD患者根据血管造影结果分为CAD-和CAD+两组。直径狭窄<50%的患者被分类为血管造影“正常”（CAD-），否则患者被分配到CAD+组。CAD+组进一步细分为单支、双支和三支血管病变（VD）。与CAD+和CAD-患者相比，对照组的血清sd-LDL浓度显著降低（P<0.001）。此外，CAD+患者的sd-LDL浓度高于CAD-患者（P<0.01）。sd-LDL水平与由狭窄冠状动脉数量定义的CAD严重程度无显著相关性（P=0.245）。所有参与者也被分为有或无代谢综合征的亚组。有代谢综合征的受试者的sd-LDL水平高于无代谢综合征的受试者（P<0.01）。多元线性回归显示，在CAD患者中，三酰甘油、总胆固醇、体重指数和腰围是血清sd-LDL浓度的最重要决定因素。我们发现，出现CAD症状的患者的sd-LDL水平显著更高。此外，冠状动脉严重狭窄（狭窄>50%）的患者与无明显病变的患者相比，sd-LDL水平更高。
