1Department of Neurology, University of Minnesota, Minneapolis, MN, USA.
Clin Appl Thromb Hemost. 2013 Nov-Dec;19(6):652-62. doi: 10.1177/1076029612454938. Epub 2012 Aug 16.
Intracerebral hemorrhage (ICH) is associated with a higher mortality rate among stroke subtypes. The amount of hematoma at baseline and subsequent expansion are considered strong independent markers for determining poor clinical outcome. Even though reduction in blood pressure to prevent and control the amount of bleeding in ICH has received considerable amount of attention, the impact of coagulopathy and platelet dysfunction, on the bleeding diathesis has not been extensively investigated. With the increasing use of antiplatelets and/or anticoagulants, given the aging population, a deeper understanding of the interactions between ICH and hemostatic mechanisms is essential to help minimize the risk of a catastrophic coagulopathy-related ICH. In this review article, etiology and risk factors associated with coagulopathy-related ICH are discussed. An overview of coagulation abnormalities, hemostatic agents, and blood biomarkers pertaining to ICH is included.
脑出血（ICH）是卒中亚型中死亡率较高的一种疾病。基线血肿量和随后的血肿扩大被认为是判断临床预后不良的强有力的独立标志物。尽管降低血压以预防和控制 ICH 中的出血量已受到广泛关注，但凝血功能障碍和血小板功能障碍对出血倾向的影响尚未得到广泛研究。随着抗血小板药物和/或抗凝药物的使用增加，鉴于人口老龄化，深入了解 ICH 和止血机制之间的相互作用对于帮助降低灾难性凝血功能障碍相关 ICH 的风险至关重要。在这篇综述文章中，讨论了与凝血功能障碍相关的 ICH 的病因和危险因素。还包括了与 ICH 相关的凝血异常、止血剂和血液生物标志物的概述。
