Faasse Kate, Gamble Greg, Cundy Tim, Petrie Keith J
Department of Psychological Medicine, University of Auckland, Auckland, New Zealand.
BMJ Open. 2012 Aug 17;2(4). doi: 10.1136/bmjopen-2012-001607. Print 2012.
This study investigated the impact of television news coverage on total adverse event reporting rates 1 month before and after the bulletins during a medication health scare. We further investigated whether individual side effects mentioned in each bulletin were reflected in the adverse event reports following the coverage.
A retrospective pre-post observational study.
New Zealand Centre for Adverse Reactions Monitoring.
Adverse events reported from May to December 2008 relating to Eltroxin formulation change.
Primary outcome measure was the total rate of adverse event reporting per day. Secondary outcome measure was the rate of reporting of seven individual symptoms mentioned in the television coverage.
After story 1, a significant increase in total reporting rates was evident (Mdn(Pre)=0, Mdn(Post)=13.5, U=2, p<0.001, r=-0.86) with larger effect sizes for increases in television-mentioned symptoms. Story 2 also showed a significant increase in total adverse event reporting (Mdn(Pre)=6, Mdn(Post)=18.5, U=86.5, p=0.002, r=-0.49) driven by significant increases only in television-reported symptoms. Story 3 did not result in a significant increase in total reporting (Mdn(Pre)=12; Mdn(Post)=15.5, U=171, p=0.432, r=-0.12), and showed a significant increase in reporting rates for only one of the two television-reported symptoms.
The findings suggest that television news coverage can impact on the overall rate of adverse event reporting during a health scare, in part via increased reporting of media-mentioned side effects. The effects of television media coverage on adverse event reporting appear strongest for earlier reports.
本研究调查了在药物健康恐慌期间，电视新闻报道对公告前后1个月内总不良事件报告率的影响。我们还进一步调查了每则公告中提到的个体副作用是否在报道后的不良事件报告中有所体现。
一项回顾性前后观察研究。
新西兰不良反应监测中心。
2008年5月至12月报告的与左旋甲状腺素制剂变更相关的不良事件。
主要观察指标是每日不良事件报告的总发生率。次要观察指标是电视报道中提到的七种个体症状的报告率。
在报道1之后，总报告率有显著增加（中位数（之前）=0，中位数（之后）=13.5，U=2，p<0.001，r=-0.86），电视提及症状的增加效应量更大。报道2也显示总不良事件报告有显著增加（中位数（之前）=6，中位数（之后）=18.5，U=86.5，p=0.002，r=-0.49），这仅由电视报道症状的显著增加所驱动。报道3并未导致总报告率显著增加（中位数（之前）=12；中位数（之后）=15.5，U=171，p=0.432，r=-0.12），并且仅两种电视报道症状中的一种报告率有显著增加。
研究结果表明，电视新闻报道在健康恐慌期间可影响不良事件报告的总体发生率，部分原因是媒体提及的副作用报告增加。电视媒体报道对不良事件报告的影响在早期报道中似乎最为强烈。
