Cakan Derya Germec, Ulkur Feyza, Taner Tulin Uğur
Department of Orthodontics, Faculty of Dentistry, Yeditepe University, Istanbul, TURKIYE.
Eur J Dent. 2012 Jul;6(3):340-5.
Successful treatment of any orthodontic problem depends on an appropriate diagnosis of its etiology. It is well known that the genetics, as well as environmental factors, play an important role on the etiology of skeletal anomalies. Recent studies and advances in genetic sciences allowed the orthodontists to better understand the effects of genetics on the etiology of dentofacial characteristics and pathologies which in turn supported the effects of the genes in the development of dentofacial complex. In orthodontic practice, the genetic basis of a skeletal anomaly should also be considered during the diagnosis. Therefore orthodontic treatment plan should be chosen accordingly. However, further genetic studies are required to clearly determine all the specific genes leading to a particular skeletal variability caused by the polygenic nature of craniofacial traits. This article includes the current information on the association between orthodontics and genetics, an outline of the evidence based impact of heredity on dentofacial development as a review of the etiological factors of skeletal anomalies from the genetic point of view.
任何正畸问题的成功治疗都取决于对其病因的恰当诊断。众所周知，遗传学以及环境因素在骨骼异常的病因中起着重要作用。遗传学领域的最新研究和进展使正畸医生能够更好地理解遗传学对牙颌面特征及病理病因的影响，这反过来也证实了基因在牙颌面复合体发育中的作用。在正畸临床实践中，诊断时也应考虑骨骼异常的遗传基础。因此，正畸治疗方案应据此选择。然而，由于颅面特征的多基因性质，需要进一步的遗传学研究来明确所有导致特定骨骼变异的具体基因。本文包含了正畸学与遗传学之间关联的当前信息，概述了遗传对牙颌面发育的循证影响，从遗传学角度对骨骼异常的病因因素进行综述。
