Matsuzaki Kyoichi, Upton Dominic
Department of Plastic and Reconstructive Surgery, Kawasaki Municipal Tama Hospital, Kawasaki.
Department of Plastic and Reconstructive Surgery, Kawasaki Municipal Tama Hospital, Kawasaki, JapanDepartment of Plastic and Reconstructive Surgery, St. Marianna University School of Medicine, Kawasaki, JapanInstitute of Health and Society, University of Worcester, Worcester, UK.
Int Wound J. 2013 Dec;10(6):638-44. doi: 10.1111/j.1742-481X.2012.01038.x. Epub 2012 Aug 21.
This review and case study report considers the evidence to indicate that the progress of wound healing is negatively affected by the presence of stressors and in circumstances where patients are in pain. It considers the relationship between perceptions of pain, stress and delayed wound healing with a specific focus on guidance for clinical practice. It is appreciated that although the literature has examined these issues in the management of acute wounds, demonstrating that psychological stress can have detrimental effects on the wound-healing process, the evidence to support this link in relation to chronic wounds is limited. The review considers evidence indicating that punch biopsy wounds heal more slowly in subjects under stress on account of caring for family members with long-term illnesses and also considers briefly the relationship between cortisol secretion in response to stress and the consequent influences on cytokine levels and the wound-healing process.
本综述及病例研究报告探讨了相关证据，表明应激源的存在以及患者处于疼痛状态会对伤口愈合进程产生负面影响。报告考虑了疼痛感知、压力与伤口愈合延迟之间的关系，并特别关注对临床实践的指导。需要认识到，尽管文献已在急性伤口管理中研究了这些问题，表明心理压力会对伤口愈合过程产生不利影响，但支持这一关联在慢性伤口方面的证据有限。该综述考虑了相关证据，这些证据表明，由于照顾患有长期疾病的家庭成员，处于压力下的受试者的穿刺活检伤口愈合得更慢，并且还简要考虑了对应激产生的皮质醇分泌与随后对细胞因子水平及伤口愈合过程的影响之间的关系。
