季节对圈养狒狒炎症反应的影响。
The effect of season on inflammatory response in captive baboons.
作者信息
McFarlane Dianne, Wolf Roman F, McDaniel Kristen A, White Gary L
机构信息
Department of Physiological Sciences, Center of Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, USA.
出版信息
J Med Primatol. 2012 Dec;41(6):341-8. doi: 10.1111/j.1600-0684.2012.00560.x. Epub 2012 Aug 21.
INTRODUCTION
Highly seasonal animals demonstrate predictable changes in immune function that coincide with changes in photoperiod. Little is known about the effect of season on immune response in baboons. The objective of this study was to determine the effect of season on inflammatory response in baboons.
MATERIALS AND METHODS
Peripheral blood mononuclear cell cytokine response following immune stimulation and serum markers of inflammation were assessed during each season in two groups of young male baboons: one housed under natural light and one in a controlled environment of 12 hours light:12 hours dark.
RESULTS
A seasonal immune rhythm was evident in both groups, with a greater TNF-α and IL-6 response to stimulation and serum CRP concentration in June and September compared with December.
CONCLUSIONS
Season is an important experimental confounder, and therefore, time of year should be controlled when designing studies and analyzing data from immune studies in baboons.
引言
季节性很强的动物会表现出与光周期变化相一致的可预测的免疫功能变化。关于季节对狒狒免疫反应的影响，人们了解甚少。本研究的目的是确定季节对狒狒炎症反应的影响。
材料与方法
在两个年轻雄性狒狒组的每个季节中，评估免疫刺激后外周血单核细胞细胞因子反应和炎症血清标志物：一组饲养在自然光下，另一组饲养在12小时光照：12小时黑暗的受控环境中。
结果
两组均出现明显的季节性免疫节律，与12月相比，6月和9月对刺激的TNF-α和IL-6反应以及血清CRP浓度更高。
结论
季节是一个重要的实验混杂因素，因此，在设计狒狒免疫研究并分析数据时，应控制一年中的时间。
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