Roubenoff R, Harris T B, Abad L W, Wilson P W, Dallal G E, Dinarello C A
Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, USA.
J Gerontol A Biol Sci Med Sci. 1998 Jan;53(1):M20-6. doi: 10.1093/gerona/53a.1.m20.
To determine the association among aging, inflammation, and cytokine production by peripheral blood mononuclear cells.
We examined production of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), IL-1 receptor antagonist (IL-1Ra), and IL-6 in 711 elderly participants in the Framingham Heart Study (mean age, 79 y) and 21 young healthy volunteers (mean age, 39 y). The elderly subjects were categorized by serum C-reactive protein (CRP) concentration, a marker of systemic inflammation.
Production of IL-6 (p < .00001) and IL-1Ra (p < .00001) was higher in the elderly subjects than in the control group. IL-6 production increased with increasing CRP, whereas IL-1RA was uniformly elevated in elderly subjects regardless of CRP. However, we found no difference in the production of IL-1 beta or TNF-alpha between the young and elderly groups, regardless of CRP status. IL-6 population correlated with IL-1 beta (r = .36, p < .0001) and TNF-alpha production (r = .25, p < .0001), but IL-1Ra production did not.
Production of IL-6 and IL-1Ra--but not IL-1 beta or TNF-alpha--was increased in the elderly compared to healthy, young subjects. The increase in IL-6 also correlated with increased production of CRP, a marker of inflammation. However, IL-1Ra was increased in the elderly independently of CRP production. Although limited by the small control group, these data suggest that dysregulation of some inflammatory cytokines occurs with age, but the role of inflammation in aging remains unclear.
确定衰老、炎症与外周血单个核细胞细胞因子产生之间的关联。
我们检测了弗雷明汉心脏研究中711名老年参与者（平均年龄79岁）和21名年轻健康志愿者（平均年龄39岁）白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）、IL-1受体拮抗剂（IL-1Ra）和IL-6的产生情况。老年受试者按全身炎症标志物血清C反应蛋白（CRP）浓度进行分类。
老年受试者中IL-6（p <.00001）和IL-1Ra（p <.00001）的产生高于对照组。IL-6的产生随CRP升高而增加，而无论CRP如何，老年受试者中IL-1RA均普遍升高。然而，无论CRP状态如何，我们发现年轻组和老年组之间IL-1β或TNF-α的产生没有差异。IL-6水平与IL-1β（r =.36，p <.0001）和TNF-α产生（r =.25，p <.0001）相关，但与IL-1Ra产生无关。
与健康年轻受试者相比，老年人中IL-6和IL-1Ra的产生增加，而IL-1β或TNF-α没有增加。IL-6的增加也与炎症标志物CRP产生的增加相关。然而，IL-1Ra在老年人中独立于CRP产生而增加。尽管受对照组规模较小的限制，但这些数据表明某些炎性细胞因子的失调随年龄增长而发生，但炎症在衰老中的作用仍不清楚。
