通过催化对映选择性亚胺异构化反应不对称合成三氟甲基化胺。
Asymmetric synthesis of trifluoromethylated amines via catalytic enantioselective isomerization of imines.
机构信息
Department of Chemistry, Brandeis University, Waltham, Massachusetts 02454-9110, USA.
出版信息
J Am Chem Soc. 2012 Sep 5;134(35):14334-7. doi: 10.1021/ja306771n. Epub 2012 Aug 23.
Abstract
A new approach toward the asymmetric synthesis of optically active trifluoromethylated amines was enabled by an unprecedented, highly enantioselective catalytic isomerization of trifluoromethyl imines with a new chiral organic catalyst. Not only aryl but also alkyl trifluoromethylated amines could be obtained in high enantioselectivities.
摘要
一种新方法通过一种前所未有的、高对映选择性的手性有机催化剂对三氟甲基亚胺的异构化反应，实现了光学活性的三氟甲基化胺的不对称合成。不仅芳基，而且烷基三氟甲基化胺也可以以高对映选择性获得。
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