Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Aalborg, Denmark.
Acta Psychiatr Scand. 2013 Jan;127(1):62-8. doi: 10.1111/j.1600-0447.2012.01913.x. Epub 2012 Aug 20.
To explore changes in the diagnosed incidence of early onset schizophrenia (EOS) from 1971 to 2010.
Examination of incidence rates of schizophrenia in patients under 18 years of age, using a nationwide, population-based, mental health register.
The age-standardized incidence rate (IR) of EOS in the period 1971-2010 was 3.17 (95% CI: 3.16, 3.18) per 100 000 person years in the age group 0-18 years, and 9.10 (95% CI: 9.00, 9.21) in the age group 12-18 years. In the period 1971-1993, the age-standardized IR of EOS was 1.80 (95% CI: 1.79, 1.82) per 100 000 person years in the age group 0-18 years, and 5.02 (95% CI: 4.92, 5.11) in the age group 12-18 years. In the period 1994-2010, the age-standardized IR of EOS was 5.15 (95% CI: 5.10, 5.20) per 100 000 person years in the age group 0-18 years, and 15.73 (95% CI: 15.22, 16.22) in the age group 12-18 years. The IR was higher for males than females in the periods 1971-1993 and 1971-2010, but in the period 1994-2010 the IR was higher for females than males.
In recent years, the diagnosed incidence of EOS has increased and the usual male excess has disappeared. The changes in IR could be a result of changes in the diagnostic system, increased awareness of early psychosis or a reflection of actual underlying incidence of the disorder.
探讨 1971 年至 2010 年早发性精神分裂症（EOS）诊断发病率的变化。
使用全国性、基于人群的心理健康登记处，检查 18 岁以下患者的精神分裂症发病率。
1971-2010 年，0-18 岁年龄组的 EOS 年龄标准化发病率（IR）为 3.17（95%CI：3.16，3.18）/10 万人年，12-18 岁年龄组为 9.10（95%CI：9.00，9.21）。在 1971-1993 年期间，0-18 岁年龄组的 EOS 年龄标准化 IR 为 1.80（95%CI：1.79，1.82）/10 万人年，12-18 岁年龄组为 5.02（95%CI：4.92，5.11）。在 1994-2010 年期间，0-18 岁年龄组的 EOS 年龄标准化 IR 为 5.15（95%CI：5.10，5.20）/10 万人年，12-18 岁年龄组为 15.73（95%CI：15.22，16.22）。在 1971-1993 年和 1971-2010 年期间，男性的发病率高于女性，但在 1994-2010 年期间，女性的发病率高于男性。
近年来，EOS 的诊断发病率有所增加，通常的男性优势已经消失。IR 的变化可能是诊断系统变化、对早期精神病认识提高或疾病实际发病率变化的反映。
