Department of Physical Medicine and Rehabilitation, Konya Education and Research Hospital, and Department of Midwifery, Health Sciences Faculty of Selcuk University, Konya, Turkey.
J Sex Med. 2012 Oct;9(10):2664-70. doi: 10.1111/j.1743-6109.2012.02882.x. Epub 2012 Aug 20.
To evaluate sexual function in women with rheumatoid arthritis (RA) and compare them with healthy controls.
Ninety-five patients with RA and 108 healthy controls were included in the study. Depression levels and sexual functions of all participants were evaluated by the Beck Depression Inventory (BDI) and Index of Female Sexual Function (IFSF), respectively. Morning stiffness in women with RA, pain (Visual Analog Scale--VAS), disability rate (Health Assessment Questionnaire--HAQ), and disease activity score (DAS-28) were defined.
Total IFSF and mean of IFSF subgroup scores and significance of sexual life score were lower in patients with RA than controls, whereas mean BDI score was higher. The mean of the total IFSF scores was significantly lower in patients with RA with BDI≥17 than that of patients with BDI<17. The mean of the total IFSF score decreased as disease severity increased. There was a strong negative correlation between total IFSF and DAS-28 scores, a moderate negative correlation between total IFSF score and HAQ, BDI, VAS score, age, and morning stiffness, and weak negative correlation between total IFSF and body mass index.
RA is observed to have negative effects on sexual functions of women. Presence of depressive symptoms with RA and increased disease severity increase the degree of sexual dysfunction. Women patients with RA should also be asked about their sexual lives while being evaluated.
评估类风湿关节炎（RA）女性患者的性功能，并与健康对照组进行比较。
本研究纳入了 95 例 RA 患者和 108 例健康对照者。采用贝克抑郁量表（BDI）和女性性功能指数（IFSF）评估所有参与者的抑郁水平和性功能。RA 女性患者的晨僵、疼痛（视觉模拟评分-VAS）、残疾率（健康评估问卷-HAQ）和疾病活动评分（DAS-28）。
RA 患者的总 IFSF 及 IFSF 亚组评分均值和性生活评分显著低于对照组，而 BDI 评分均值较高。BDI≥17 的 RA 患者的总 IFSF 评分均值显著低于 BDI<17 的患者。随着疾病严重程度的增加，总 IFSF 评分呈下降趋势。总 IFSF 评分与 DAS-28 评分呈强负相关，与 HAQ、BDI、VAS 评分、年龄和晨僵呈中度负相关，与 BMI 呈弱负相关。
RA 对女性性功能有负面影响。存在 RA 伴抑郁症状和疾病严重程度增加会增加性功能障碍的程度。在评估 RA 女性患者时，也应询问其性生活情况。
