PPSM, ENS-Cachan, 61 avenue du Président Wilson, 94235 Cachan Cedec, France.
Photochem Photobiol Sci. 2012 Nov;11(11):1737-43. doi: 10.1039/c2pp25103e.
A series of fluorescent sensor molecules based on a phosphane sulfide derivative that is soluble in an organoaqueous solvent were designed and synthesized. The structure of the fluorophore has been optimized in order to have the best compromise in terms of solubility and photophysical properties. The obtained properties are in full agreement with quantum chemical calculations. A fluorescent molecular sensor containing one polyoxoethylene group has been synthesized and an efficient quenching upon mercury complexation has been observed. Finally, this sensing molecule has been introduced in a microfluidic chip in which fluorescence detection has been integrated. An efficient fluorescence response was observed upon mercury addition.
设计并合成了一系列基于膦硫醚衍生物的荧光传感器分子，该衍生物可溶于有机溶剂/水混合物。为了在溶解度和光物理性质方面达到最佳平衡，对荧光团的结构进行了优化。所得性质与量子化学计算完全一致。合成了一种含有一个聚氧乙烯基团的荧光分子传感器，并观察到其与汞配合物的有效猝灭。最后，将这种传感分子引入微流控芯片中，集成了荧光检测功能。加入汞后观察到了有效的荧光响应。
