利用功能化液晶微滴中的回音壁模式激光检测重金属离子。
Detection of heavy metal ions using whispering gallery mode lasing in functionalized liquid crystal microdroplets.
作者信息
Duan Rui, Li Yanzeng, Li Hanyang, Yang Jun
机构信息
College of Physics and Photoelectric Engineering, Harbin Engineering University, Harbin 150001, China.
Key Lab of In-fiber Integrated Optics, Ministry Education of China, Harbin Engineering University, Harbin 150080, China.
出版信息
Biomed Opt Express. 2019 Nov 5;10(12):6073-6083. doi: 10.1364/BOE.10.006073. eCollection 2019 Dec 1.
We demonstrate a detection method for heavy metal (HM) ions based on whispering gallery mode (WGM) lasing in a liquid crystal (LC) microdroplet biosensor. By doping with stearic acid, nematic LC 4-cyano-4'-pentylbiphenyl (5CB) microdroplets are biochemically functionalized and used as both optical microresonators and sensing elements. Typical WGM lasing emission is observed in stearic acid-doped 5CB microdroplets under a pulse laser pump. Our results show that quantitative spectral shift of WGMs can serve as a real-time indicator of the adsorption of HM ions on the microdroplet surface. The detection limit of our sensor is as low as 40 pM for Cu(II) ions, six orders of magnitude better than the exposure threshold defined by the World Health Organization. Furthermore, this sensing system has an ability to discriminate between heavy and light metal ions. We believe that this novel biosensor has great application potential for environmental monitoring and drinking water quality testing.
我们展示了一种基于液晶（LC）微滴生物传感器中的回音壁模式（WGM）激光发射来检测重金属（HM）离子的方法。通过掺杂硬脂酸，向列型液晶4-氰基-4'-戊基联苯（5CB）微滴实现了生物化学功能化，并用作光学微谐振器和传感元件。在脉冲激光泵浦下，在掺杂硬脂酸的5CB微滴中观察到了典型的WGM激光发射。我们的结果表明，WGM的定量光谱位移可作为HM离子在微滴表面吸附的实时指标。我们的传感器对铜（II）离子的检测限低至40 pM，比世界卫生组织定义的暴露阈值好六个数量级。此外，这种传感系统有能力区分重金属离子和轻金属离子。我们相信，这种新型生物传感器在环境监测和饮用水质量检测方面具有巨大的应用潜力。
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