Hertel V, Schick B
Hals-, Nasen- und Ohrenklinik, Universitätsklinikum des Saarlandes, Kirrberger Strasse, Gebäude 6, 66421 Homburg, Germany.
Laryngorhinootologie. 2012 Sep;91(9):585-97. doi: 10.1055/s-0032-1316382. Epub 2012 Aug 20.
Independent of its origin a frontobasal cerebrospinal fluid (CSF) fistula is characterized by an open connection between the intracranial space with the outside world (usually the nose and paranasal sinuses). It leads to loss of CSF and is associated with a significant risk of developing meningitis for the patient during further life. Precise knowledge of possible aetiologies, clinical symptoms, current diagnostic options and surgical strategies are essential for the detection and successful management of frontobasal CSF fi fistulas. This article summarizes aetiology and clinical signs of frontobasal CSF fistulas. Further, laboratory tests to analyse fluid samples for cerebrospinal fluid as well as radiological and endoscopic investigation methods aiming to localize a CSF-fistula are presented. Finally, surgical techniques to close a frontobasal CSF fistula are explained.
无论其起源如何,额底脑脊液(CSF)瘘的特征是颅内空间与外界(通常是鼻腔和鼻窦)之间存在开放连接。它会导致脑脊液流失,并使患者在今后的生活中面临发生脑膜炎的重大风险。准确了解可能的病因、临床症状、当前的诊断方法和手术策略对于额底脑脊液瘘的检测和成功治疗至关重要。本文总结了额底脑脊液瘘的病因和临床体征。此外,还介绍了用于分析液体样本是否为脑脊液的实验室检查,以及旨在定位脑脊液瘘的放射学和内镜检查方法。最后,解释了闭合额底脑脊液瘘的手术技术。