通过氮杂-Prins 环化反应不对称合成（-）-戊诺啡和（-）-依他佐辛。
Asymmetric syntheses of (-)-pentazocine and (-)-eptazocine through an aza-Prins cyclization.
机构信息
State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou 730000, PR China.
出版信息
Chem Asian J. 2012 Nov;7(11):2543-6. doi: 10.1002/asia.201200505. Epub 2012 Aug 21.
PMID:22907930
Abstract
Two down more to go: The asymmetric syntheses of (-)-pentazocine and (-)-eptazocine are presented. The highlights of the syntheses are the construction of the core skeleton through an aza-Prins cyclization and intramolecular Friedel-Crafts reaction.
摘要
还有两步就完成了
呈现了（-）-戊诺啡和（-）-依他佐辛的不对称合成。合成的重点是通过氮杂-Prins 环化和分子内傅克反应构建核心骨架。
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