Musikaeva M V
Probl Tuberk. 1990(11):23-5.
The outcomes of treatment of 217 patients aged 50 or over with newly diagnosed destructive pulmonary tuberculosis were analysed. Their management included the following 3 regimens: Groups 1 and 2 were on intermittent regimen with drugs introduced parenterally, and Group 3 was on a daily regimen with drugs introduced orally. The intermittent regimens can compete with a daily one, whereas a parenteral administration of all the three drugs (Group 2) can even surpass it in to its efficacy. Cavity closure rate was registered in 74.2, 81.4 and 60.0% in the Groups 1, 2 and 3, respectively. If compared to a daily oral administration, the intermittent one leads to the elimination of destructive changes in the lungs more rapidly and in a shorter period of time. A significant improvement of tolerance to the intermittent drug administration and a decrease in the prescribed medicinal load on the body are noted.
对217例年龄在50岁及以上新诊断为破坏性肺结核的患者的治疗结果进行了分析。他们的治疗方案包括以下3种：第1组和第2组采用间歇方案，药物通过胃肠外途径给药，第3组采用每日方案，药物口服给药。间歇方案可以与每日方案相媲美，而三种药物均通过胃肠外途径给药（第2组）在疗效上甚至可以超过每日方案。第1、2和3组的空洞闭合率分别为74.2%、81.4%和60.0%。与每日口服给药相比，间歇给药能更快且在更短时间内消除肺部的破坏性病变。观察到对间歇给药的耐受性显著改善，且身体上规定的药物负荷降低。
