Cheren'ko S A
Probl Tuberk. 1989(8):48-50.
Forty patients with chronic destructive tuberculosis of the lung and concomitant diabetes mellitus treated with the routine chemotherapeutic agents without any effect were subjected to intermittent polychemotherapy. Combinations of 4, 5 and 6 drugs were used. Some of them were administered intermittently. The period of the polychemotherapy ranged from 4 to 8 months and was followed by less intensive regimens. It was shown that the polychemotherapy allowed one to increase the treatment efficacy in the patients with chronic destructive tuberculosis of the lung and concomitant diabetes mellitus. Discontinuation of tubercle bacilli isolation, cavern healing and partial cavern regression were observed in 25 (63 per cent), 11 (26 per cent) and 27 (54 per cent) patients, respectively. The clinical picture did not change in 6 patients (15 per cent). Adverse reactions to the polychemotherapy developed in 17 patients (42.5 per cent). Markedly pronounced adverse reactions requiring discontinuation of the drug use in 7 (17.5 per cent) of them were recorded. Lowering a dose of the drug, applying corticosteroids, pyridoxine, nicotinic acid, cerucal, lipamide, carsyl and unithiol allowed one to eliminate the adverse reactions developed.
40例慢性毁损性肺结核合并糖尿病患者，采用常规化疗药物治疗无效后，接受了间歇联合化疗。使用了4种、5种和6种药物的联合方案。部分药物采用间歇给药。联合化疗疗程为4至8个月，之后采用强度较低的治疗方案。结果表明，联合化疗能够提高慢性毁损性肺结核合并糖尿病患者的治疗效果。分别有25例（63%）、11例（26%）和27例（54%）患者痰菌转阴、空洞愈合及部分空洞缩小。6例患者（15%）病情无变化。17例患者（42.5%）出现联合化疗不良反应。其中7例（17.5%）出现明显不良反应，需要停药。减少药物剂量、应用皮质类固醇、吡哆醇、烟酸、西卢卡尔、硫辛酸、卡西尔和二巯基丙醇可消除出现的不良反应。
