结节病性葡萄膜炎中的血管紧张素转换酶

Angiotensin-converting enzyme in sarcoid uveitis.

作者信息

Weinreb R N, O'Donnell J J, Sandman R, Char D H, Kimura S J

出版信息

Invest Ophthalmol Vis Sci. 1979 Dec;18(12):1285-7.

Abstract

The diagnosis of ocular sarcoid is presumptive in the absence of systemic disease. The association of elevated serum angiotensin-converting enzyme (ACE) levels with active systemic sarcoid has been well described. With a sensitive fluorimetric assay for ACE, we found that five of ten chronic granulomatous uveitis patients without systemic sarcoid had elevated serum ACE levels. None of ten patients with uveitis of known etiology had elevated serum ACE levels. We believe that the association of an elevated serum ACE level with chronic granulomatous uveitis suggests the diagnosis of ocular sarcoid.

摘要

在无全身性疾病的情况下，眼部结节病的诊断是推测性的。血清血管紧张素转换酶（ACE）水平升高与活动性全身性结节病之间的关联已得到充分描述。通过一种灵敏的ACE荧光测定法，我们发现10例无全身性结节病的慢性肉芽肿性葡萄膜炎患者中有5例血清ACE水平升高。10例已知病因的葡萄膜炎患者中无一例血清ACE水平升高。我们认为血清ACE水平升高与慢性肉芽肿性葡萄膜炎之间的关联提示眼部结节病的诊断。