结膜结节病和睑板腺囊肿肉芽肿中的血管紧张素转换酶。

Angiotensin-converting enzyme in sarcoid and chalazion granulomas of the conjunctiva.

作者信息

Immonen I, Friberg K, Grönhagen-Riska C, von Willebrand E, Fyhrquist F

出版信息

Acta Ophthalmol (Copenh). 1986 Oct;64(5):519-21. doi: 10.1111/j.1755-3768.1986.tb06965.x.

DOI:10.1111/j.1755-3768.1986.tb06965.x

Abstract

Angiotensin-converting enzyme (ACE) was studied immunohistochemically in conjunctival biopsies from 6 patients with systemic sarcoidosis, 4 patients with posterior non-sarcoid uveitis and in specimens from 4 patients with chalazion of the eyelid. Specimens with sarcoid granulomas showed intense ACE-positive immunoreactivity in epitheloid cells of the granuloma, whereas chalazion granulomas did not contain ACE-immunoreactivity. There was no difference in staining patterns between specimens without granulomas. Thus immunohistochemical staining for ACE may be of help in differentiating conjunctival granulomatous tissue of a chalazion from sarcoid granuloma.

摘要

采用免疫组织化学方法，对6例系统性结节病患者、4例后部非结节性葡萄膜炎患者的结膜活检组织以及4例睑板腺囊肿患者的标本进行了血管紧张素转换酶（ACE）研究。有结节病肉芽肿的标本在肉芽肿的上皮样细胞中显示出强烈的ACE阳性免疫反应，而睑板腺囊肿肉芽肿则没有ACE免疫反应。无肉芽肿的标本之间染色模式没有差异。因此，ACE免疫组织化学染色可能有助于鉴别睑板腺囊肿的结膜肉芽肿组织与结节病肉芽肿。