茶碱能够部分逆转荷瘤大鼠的恶病质。
Theophylline is able to partially revert cachexia in tumour-bearing rats.
机构信息
Cancer Research Group, Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, Barcelona, 08028, Spain.
出版信息
Nutr Metab (Lond). 2012 Aug 21;9(1):76. doi: 10.1186/1743-7075-9-76.
BACKGROUND AND AIMS
The aim of the present investigation was to examine the anti-wasting effects of theophylline (a methylxantine present in tea leaves) on a rat model of cancer cachexia.
METHODS
The in vitro effects of the nutraceuticals on proteolysis were examined on muscle cell cultures submitted to hyperthermia. Individual muscle weights, muscle gene expression, body composition and cardiac function were measured in rats bearing the Yoshida AH-130 ascites hepatoma, following theophylline treatment.
RESULTS
Theophylline treatment inhibited proteolysis in C2C12 cell line and resulted in an anti-proteolytic effect on muscle tissue (soleus and heart), which was associated with a decrease in circulating TNF-alpha levels and with a decreased proteolytic systems gene expression. Treatment with the nutraceutical also resulted in an improvement in body composition and cardiac function.
CONCLUSION
Theophylline - alone or in combination with drugs - may be a candidate molecule for the treatment of cancer cachexia.
背景和目的
本研究旨在探讨茶碱（茶叶中含有的甲基黄嘌呤）对癌症恶病质大鼠模型的抗消瘦作用。
方法
在肌肉细胞培养物接受高温处理的情况下，研究了营养保健品对蛋白水解的体外影响。在患有 Yoshida AH-130 腹水肝癌的大鼠中，在茶碱治疗后测量了个体肌肉重量、肌肉基因表达、身体成分和心脏功能。
结果
茶碱治疗抑制了 C2C12 细胞系中的蛋白水解，并对肌肉组织（比目鱼肌和心脏）产生了抗蛋白水解作用，这与循环 TNF-α水平的降低以及蛋白水解系统基因表达的降低有关。营养保健品的治疗还改善了身体成分和心脏功能。
结论
茶碱——单独或与药物联合使用——可能是治疗癌症恶病质的候选分子。
Zotero 插件