药物滥用的表观遗传学：易感性或反应性。
Epigenetics of drug abuse: predisposition or response.
机构信息
Menninger Department of Psychiatry & Behavioral Sciences, Baylor College of Medicine & the Michael E DeBakey VA Medical Center, 2002 Holcombe Boulevard, Houston, TX 77030, USA.
出版信息
Pharmacogenomics. 2012 Jul;13(10):1149-60. doi: 10.2217/pgs.12.94.
Abstract
Drug addiction continues to be a serious medical and social problem. Vulnerability to develop an addiction to drugs is dependent on genetic, environmental, social and biological factors. In particular, the interactions of environmental and genetic factors indicate the significance of epigenetic mechanisms, which have been found to occur in response to illicit drug use or as underlying factors in chronic substance abuse and relapse. Epigenetics is defined as the heritable and possibly reversible modifications in gene expression that do not involve alterations in the DNA sequence. This review discusses the various types of epigenetic modifications and their relevance to drug addiction to elucidate whether epigenetics is a predisposing factor, or a response to, developing an addiction to drugs of abuse.
摘要
药物成瘾仍然是一个严重的医学和社会问题。易患药物成瘾的脆弱性取决于遗传、环境、社会和生物因素。特别是，环境和遗传因素的相互作用表明了表观遗传机制的重要性，这些机制已经被发现是对非法药物使用的反应，或者是慢性物质滥用和复发的潜在因素。表观遗传学被定义为基因表达的可遗传且可能是可逆的修饰，而不涉及 DNA 序列的改变。这篇综述讨论了各种类型的表观遗传修饰及其与药物成瘾的相关性，以阐明表观遗传学是成瘾的一个倾向因素，还是对滥用药物成瘾的反应。
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