Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, 130-701, Korea.
Endocrine. 2013 Feb;43(1):161-9. doi: 10.1007/s12020-012-9783-z. Epub 2012 Nov 3.
Toll-like receptors (TLRs) are important components of innate immune response. The aim of this study was to investigate whether TLR gene cluster (TLR10-TLR1-TLR6) polymorphisms are associated with the etiology of papillary thyroid carcinoma (PTC) and its clinicopathologic characteristics. We recruited 94 PTC patients and 325 control subjects. Genotypes for each SNP were determined by direct sequencing. SNPStats and SPSS 18.0 were used to evaluate odds ratios (ORs), 95 % confidence intervals (CIs), and P values. Multiple logistic regression analyzes of genetic data were performed. The missense SNP rs11466653 was associated with small tumor size (<1 cm) in PTC. The frequency of the rs11466653 T allele was higher in PTC patients with tumors <1 cm in size than in the control group (95.8 vs. 87.2 %; P = 0.021, OR = 0.30, 95 % CI = 0.11-0.83). The T allele of rs11466653 (T/C, Met326Thr) in TLR10 may be a risk factor for the development of tumors in PTC in the Korean population.
Toll 样受体（TLRs）是先天免疫反应的重要组成部分。本研究旨在探讨 TLR 基因簇（TLR10-TLR1-TLR6）多态性是否与甲状腺乳头状癌（PTC）的病因及其临床病理特征有关。我们招募了 94 名 PTC 患者和 325 名对照者。通过直接测序确定每个 SNP 的基因型。使用 SNPStats 和 SPSS 18.0 来评估比值比（OR）、95%置信区间（CI）和 P 值。对遗传数据进行了多元逻辑回归分析。错义 SNP rs11466653 与 PTC 中的小肿瘤大小（<1 cm）有关。在肿瘤大小<1 cm 的 PTC 患者中，rs11466653 T 等位基因的频率高于对照组（95.8%比 87.2%；P = 0.021，OR = 0.30，95%CI = 0.11-0.83）。TLR10 中的 rs11466653（T/C，Met326Thr）T 等位基因可能是韩国人群 PTC 肿瘤发生的危险因素。
