IL23/Th17 通路中的基因-基因相互作用导致汉族人群易患银屑病。
Gene-gene interactions in IL23/Th17 pathway contribute to psoriasis susceptibility in Chinese Han population.
机构信息
Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China.
出版信息
J Eur Acad Dermatol Venereol. 2013 Sep;27(9):1156-62. doi: 10.1111/j.1468-3083.2012.04683.x. Epub 2012 Aug 22.
BACKGROUND
Psoriasis is a common chronic inflammatory skin disease. IL23/Th17 is a newly confirmed pathway in psoriasis.
OBJECTIVE
To investigate the gene-gene interactions in IL23/Th17 pathway underlying psoriasis.
METHODS
A total of 299 single-nucleotide polymorphisms from 11 genes in IL23/Th17 pathway were genotyped on 1139 patients with psoriasis and 1694 controls. Multifactor dimensionality reduction and logistic regression algorithms were applied to explore the gene-gene interactions.
RESULTS
We found that there were a three-way interaction among IL21, CCR4 and TNF(χ(2) = 5.02(1), P = 0.025) and three pair-wise gene-gene interactions between IL12RB1 and CCR4(χ(2) = 11.66(4), P = 0.0201), IL22 and CCR4 (χ(2) = 11.97(4), P = 0.0176), IL12RB1 and IL6 (χ(2) = 7.31(1), P = 0.0069) in psoriasis.
CONCLUSIONS
Our results might be helpful for explaining the missing heritability of the psoriasis due to epistasis and provide a deep insight into the important role of the IL23/Th17 pathway in the pathogenesis of psoriasis.
背景
银屑病是一种常见的慢性炎症性皮肤病。IL23/Th17 是一种新确认的银屑病发病途径。
目的
探讨银屑病中 IL23/Th17 通路的基因-基因相互作用。
方法
对 1139 例银屑病患者和 1694 例对照者的 11 个基因中 299 个单核苷酸多态性进行基因分型。应用多因子降维分析和逻辑回归算法探讨基因-基因相互作用。
结果
我们发现 IL21、CCR4 和 TNF 之间存在三向相互作用（χ(2) = 5.02(1)，P = 0.025），以及 IL12RB1 和 CCR4（χ(2) = 11.66(4)，P = 0.0201）、IL22 和 CCR4（χ(2) = 11.97(4)，P = 0.0176）、IL12RB1 和 IL6（χ(2) = 7.31(1)，P = 0.0069）之间存在三对两两基因-基因相互作用。
结论
我们的研究结果可能有助于解释由于上位性导致的银屑病遗传缺失，并深入了解 IL23/Th17 通路在银屑病发病机制中的重要作用。
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