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戊糖片球菌 GMNL-77 抑制咪喹莫特诱导的银屑病样小鼠的皮肤损伤。

Lactobacillus pentosus GMNL-77 inhibits skin lesions in imiquimod-induced psoriasis-like mice.

机构信息

Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung-Hsing University, Taichung, Taiwan.

Department of Dermatology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

出版信息

J Food Drug Anal. 2017 Jul;25(3):559-566. doi: 10.1016/j.jfda.2016.06.003. Epub 2016 Aug 5.

DOI:10.1016/j.jfda.2016.06.003
PMID:28911642
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9328808/
Abstract

Psoriasis, which is regarded as a T-cell-mediated chronic inflammatory skin disease, is characterized by hyperproliferation and poor differentiation of epidermal keratinocytes. In this study, we aimed to determine the in vivo effect of a potentially probiotic strain, Lactobacillus pentosus GMNL-77, in imiquimod-induced epidermal hyperplasia and psoriasis-like skin inflammation in BALB/c mice. Oral administration of L. pentosus GMNL-77 significantly decreased erythematous scaling lesions. Real-time polymerase chain reaction showed that treatment with L. pentosus GMNL-77 significantly decreased the mRNA levels of proinflammatory cytokines, including tumor necrosis factor-alpha, interleukin (IL)-6, and the IL-23/IL-17A axis-associated cytokines (IL-23, IL-17A/F, and IL-22) in the skin of imiquimod-treated mice. In addition, we found that L. pentosus GMNL-77 decreased the spleen weights of the imiquimod-treated group and reduced the numbers of IL-17- and IL-22-producing CD4 T cells in the spleen. In conclusion, the present study provides insight into the potential use of L. pentosus GMNL-77 in the future treatment of psoriasis.

摘要

银屑病被认为是一种 T 细胞介导的慢性炎症性皮肤病，其特征是表皮角质形成细胞过度增殖和分化不良。在这项研究中，我们旨在确定潜在益生菌菌株戊糖片球菌 GMNL-77 在咪喹莫特诱导的表皮过度增生和银屑病样皮肤炎症中的体内作用。戊糖片球菌 GMNL-77 的口服给药显著减少了红斑鳞屑病变。实时聚合酶链反应显示，戊糖片球菌 GMNL-77 处理显著降低了咪喹莫特处理小鼠皮肤中促炎细胞因子的 mRNA 水平，包括肿瘤坏死因子-α、白细胞介素 (IL)-6 和 IL-23/IL-17A 轴相关细胞因子 (IL-23、IL-17A/F 和 IL-22)。此外，我们发现戊糖片球菌 GMNL-77 降低了咪喹莫特处理组的脾脏重量，并减少了脾脏中产生 IL-17 和 IL-22 的 CD4 T 细胞数量。总之，本研究为戊糖片球菌 GMNL-77 在未来治疗银屑病中的潜在用途提供了新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab0d/9328808/426fd158346f/jfda-25-03-559f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab0d/9328808/c08e724c4ee6/jfda-25-03-559f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab0d/9328808/f354efcea14f/jfda-25-03-559f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab0d/9328808/c4a51d23201b/jfda-25-03-559f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab0d/9328808/426fd158346f/jfda-25-03-559f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab0d/9328808/c08e724c4ee6/jfda-25-03-559f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab0d/9328808/f354efcea14f/jfda-25-03-559f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab0d/9328808/c4a51d23201b/jfda-25-03-559f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab0d/9328808/426fd158346f/jfda-25-03-559f4.jpg

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