Key Laboratory of Green Chemistry and Technology (Ministry of Education), College of Chemistry, Sichuan University, Chengdu, 610064, PR China.
J Org Chem. 2012 Sep 21;77(18):8350-4. doi: 10.1021/jo301196m. Epub 2012 Aug 29.
A multifunctional fluorescent sensor based on a cyclen-appended BINOL derivative (R-1) was synthesized and characterized. It can display on-off-type fluorescence change with high selectivity toward Cu(II) among 19 metal ions in 100% aqueous solution. Furthermore, the in situ generated R-1-Cu(II) ensemble could recover the quenched fluorescence upon the addition of sulfide anion resulting in a off-on-type sensing with a detection limit of micromolar range in the same medium. No interference was observed from other biothiols and anions, including GSH, l-Cys, DTT, and sulfates, making it a highly sensitive and selective sulfide probe.
基于环戊二烯基联萘衍生物（R-1）合成了一种多功能荧光传感器，并对其进行了表征。它可以在 100%水溶液中对 Cu(II)表现出高选择性的开-关型荧光变化，在 19 种金属离子中。此外，在原位生成的 R-1-Cu(II)配合物中，加入硫离子后可恢复被猝灭的荧光，从而在同一介质中实现了具有微摩尔检测限的关-开型传感。在包括 GSH、l-Cys、DTT 和硫酸盐在内的其他生物硫醇和阴离子中，没有观察到干扰，使其成为一种高灵敏度和选择性的硫化物探针。
