Recent progress in HS activated diagnosis and treatment agents.

Hydrogen sulfide (HS) is a key biosignal molecule in the human body. Endogenous HS, as a gas delivery and protective agent in the body, is involved in a variety of physiological processes, including mediating vascular tone and neuromodulation. The production of abnormal HS levels in the body is related to the occurrence of various diseases, so real-time monitoring of HS is very important. However, traditional detection methods face enormous challenges in the detection of HS owing to its high volatility and rapid catabolism. Optical probes developed in recent years with the advantages of high sensitivity, short response time, non-invasive nature and capacity for real-time monitoring can overcome the limitations of traditional detection methods and offer the possibility of real-time monitoring of HS in cells and . In addition, the production of high concentrations of HS is closely related to the formation of colon cancer, and HS-activated treatment agents have been developed for use in this particular tumor microenvironment, which reduce the toxic side effects of traditional therapy on normal tissues and improves the treatment effect. This review summarizes the recent advances in HS detection probes and , as well as HS-activated tumor treatment agents.