Wang Xiaodong, An Lu, Tian Qiwei, Cui Kuili
The Key Laboratory of Resource Chemistry of the Ministry of Education, The Shanghai Key Laboratory of Rare Earth Functional Materials, The Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University Shanghai 200234 China
Department of Tuberculosis, The First Affiliated Hospital of Xinxiang Medical University China.
RSC Adv. 2019 Oct 18;9(58):33578-33588. doi: 10.1039/c9ra06698e.
Hydrogen sulfide (HS) is a key biosignal molecule in the human body. Endogenous HS, as a gas delivery and protective agent in the body, is involved in a variety of physiological processes, including mediating vascular tone and neuromodulation. The production of abnormal HS levels in the body is related to the occurrence of various diseases, so real-time monitoring of HS is very important. However, traditional detection methods face enormous challenges in the detection of HS owing to its high volatility and rapid catabolism. Optical probes developed in recent years with the advantages of high sensitivity, short response time, non-invasive nature and capacity for real-time monitoring can overcome the limitations of traditional detection methods and offer the possibility of real-time monitoring of HS in cells and . In addition, the production of high concentrations of HS is closely related to the formation of colon cancer, and HS-activated treatment agents have been developed for use in this particular tumor microenvironment, which reduce the toxic side effects of traditional therapy on normal tissues and improves the treatment effect. This review summarizes the recent advances in HS detection probes and , as well as HS-activated tumor treatment agents.
硫化氢（HS）是人体中的一种关键生物信号分子。内源性HS作为体内的气体传递和保护剂，参与多种生理过程，包括调节血管张力和神经调节。体内HS水平异常产生与多种疾病的发生有关，因此对HS进行实时监测非常重要。然而，由于HS具有高挥发性和快速分解代谢的特点，传统检测方法在检测HS时面临巨大挑战。近年来开发的光学探针具有高灵敏度、短响应时间、非侵入性以及实时监测能力等优点，能够克服传统检测方法的局限性，并为在细胞和体内实时监测HS提供了可能性。此外，高浓度HS的产生与结肠癌的形成密切相关，并且已经开发出用于这种特定肿瘤微环境的HS激活治疗剂，其可减少传统疗法对正常组织的毒副作用并提高治疗效果。本综述总结了HS检测探针以及HS激活的肿瘤治疗剂的最新进展。
