National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
Cancer Epidemiol. 2012 Dec;36(6):513-8. doi: 10.1016/j.canep.2012.08.001. Epub 2012 Aug 19.
American Seventh-day Adventists have been reported to have lower cancer mortality and incidence than the general population. Adventists do not consume tobacco, alcohol or pork, and many adhere to a lacto-ovo-vegetarian lifestyle. Baptists discourage excessive use of alcohol and tobacco. In this study, we investigated whether the incidence of cancer in a large cohort of Danish Adventists and Baptists was different compared to the general Danish population.
We followed 11,580 Danish Adventists and Baptists in the nationwide Danish Cancer Registry, which contains information on cases of cancer for 1943-2008. Cancer incidence in the cohort was compared with that in the general Danish population as standardized incidence ratios (SIRs) with 95% confidence intervals (CIs), and within-cohort comparisons were made with a Cox model.
Lower cancer incidences were observed for both Seventh-day Adventist men (SIR, 66; 95% CI, 60-72) and women (85; 80-91). The same result was observed for Baptists although not as low. The differences were most pronounced for smoking-related cancers such as those of the buccal cavity and lung (SIR, 20; 13-30 for Seventh-day Adventist men and 33; 22-49 for Seventh-day Adventist women). The incidences of other lifestyle-related cancers, such as of stomach, rectum, liver and cervix, were also decreased. In general, the SIRs were lower for men than for women, and Adventists had lower hazard rates than Baptists.
Our findings point to the benefits of compliance with public health recommendations and indicate that lifestyle changes in the population might change the cancer risks of individuals.
据报道，美国的基督复临安息日会教徒的癌症死亡率和发病率低于普通人群。安息日会教徒不吸烟、不饮酒、不吃猪肉，许多人遵循乳蛋素食主义的生活方式。浸礼会教徒则反对过度饮酒和吸烟。在这项研究中，我们调查了丹麦基督复临安息日会教徒和浸礼会教徒的大样本队列中癌症的发病率是否与丹麦普通人群不同。
我们在全国性的丹麦癌症登记处中对 11580 名丹麦基督复临安息日会教徒和浸礼会教徒进行了随访，该登记处包含了 1943 年至 2008 年的癌症病例信息。使用标准化发病比（SIR）及其 95%置信区间（CI），将队列中的癌症发病率与丹麦普通人群进行比较，并使用 Cox 模型进行队列内比较。
男性（SIR 为 66；95%CI 为 60-72）和女性（SIR 为 85；80-91）基督复临安息日会教徒的癌症发病率均较低。浸礼会教徒的结果虽然不那么低，但也观察到了相似的结果。这种差异在与吸烟有关的癌症中最为明显，如口腔和肺部的癌症（男性 SIR 为 20；13-30，女性 SIR 为 33；22-49）。其他与生活方式相关的癌症，如胃癌、直肠癌、肝癌和宫颈癌的发病率也有所下降。一般来说，男性的 SIR 低于女性，而安息日会教徒的危险率低于浸礼会教徒。
我们的发现表明了遵守公共卫生建议的好处，并指出人群中生活方式的改变可能会改变个体的癌症风险。
