Kørup Alex Kappel, Thygesen Lau Caspar, Christensen René dePont, Johansen Christoffer, Søndergaard Jens, Hvidt Niels Christian
Research Unit of General Practice, University of Southern Denmark, Odense, Denmark.
National Institute of Public Health, Copenhagen, Denmark.
BMJ Open. 2016 Mar 25;6(3):e010128. doi: 10.1136/bmjopen-2015-010128.
Studies comprising Danish Seventh-day Adventists (SDAs) and Danish Baptists found that members have a lower risk of chronic diseases including cancer. Explanations have pointed to differences in lifestyle, but detailed aetiology has only been sparsely examined. Our objective was to investigate the incidence of sexually transmitted diseases (STDs) among Danish SDAs and Baptists as a proxy for cancers related to sexual behaviour.
We followed the Danish Cohort of Religious Societies from 1977 to 2009, and linked it with national registers of all inpatient and outpatient care contacts using the National Patient Register. We compared the incidence of syphilis, gonorrhoea and chlamydia among members of the cohort with the general population.
The cohort comprised 3119 SDA females, 1856 SDA males, 2056 Baptist females and 1467 Baptist males. For the entire cohort, we expected a total of 32.4 events of STD, and observed only 9. Female SDAs and Baptists aged 20-39 years had significant lower incidence of chlamydia (both p<0.001). Male SDAs and Baptists aged 20-39 years also had significant lower incidence of chlamydia (p<0.01 and p<0.05, respectively). No SDA members were diagnosed with gonorrhoea, when 3.4 events were expected, which, according to Hanley's 'rule of three', is a significant difference. No SDA or Baptist was diagnosed with syphilis.
The cohort shows significant lower incidence of STD, most likely including human papillomavirus, which may partly explain the lower incidence of cancers of the cervix, rectum, anus, head and neck.
针对丹麦基督复临安息日会（SDA）成员和丹麦浸信会成员的研究发现，这些群体患包括癌症在内的慢性病风险较低。相关解释指向生活方式的差异，但详细病因仅得到了较少的研究。我们的目标是调查丹麦SDA成员和浸信会成员中性传播疾病（STD）的发病率，以此作为与性行为相关癌症的一个指标。
我们对1977年至2009年的丹麦宗教团体队列进行了随访，并使用国家患者登记册将其与所有住院和门诊护理接触的国家登记册相链接。我们比较了该队列成员与普通人群中梅毒、淋病和衣原体感染的发病率。
该队列包括3119名SDA女性、1856名SDA男性、2056名浸信会女性和1467名浸信会男性。对于整个队列，我们预计总共会有32.4例STD事件发生，但实际仅观察到9例。20至39岁的SDA女性和浸信会女性衣原体感染发病率显著较低（均p<0.001）。20至39岁的SDA男性和浸信会男性衣原体感染发病率也显著较低（分别为p<0.01和p<0.05）。预计会有3.4例淋病事件发生，但没有SDA成员被诊断出患有淋病，根据汉利的“三倍法则”，这是一个显著差异。没有SDA或浸信会成员被诊断出患有梅毒。
该队列显示STD发病率显著较低，很可能包括人乳头瘤病毒感染，这可能部分解释了子宫颈癌、直肠癌、肛门癌、头颈癌发病率较低的原因。
