Thygesen Lau Caspar, Gimsing Louise NØrreslet, Bautz Andrea, Hvidt Niels Christian, Johansen Christoffer
National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
Clinical Department of Neurology, Glostrup Hospital, Glostrup, Denmark.
J Alzheimers Dis. 2017;56(4):1429-1435. doi: 10.3233/JAD-160710.
Limited knowledge of the influence of lifestyle risk factors and religious living on chronic neurological diseases exists. Seventh-day Adventists (SDA) do not consume tobacco, alcohol, or pork, and many adhere to lacto-ovo-vegetarian diet, and Baptists discourage excessive use of alcohol and tobacco.
We investigated whether the incidence of four common chronic neurological illnesses: dementia, Alzheimer's disease, Parkinson's disease, and epilepsy in a large cohort of Danish Adventists and Baptists was different compared to the general Danish population. Three of the illnesses are neurodegenerative, whereas epilepsy can occur at any age.
We compared hospital admission rates for some major neurological diseases among members of the Danish Religious Societies Health Study comprising 6,532 SDA and 3,720 Baptists with the general Danish population. Standardized incidence ratios (SIR) stratified by sex, age, and calendar time were calculated.
SIR of dementia or Alzheimer's disease was significantly decreased for members of both communities (SDA, 0.78; 95% CI, 0.67-#x2013;0.90 and Baptists, 0.59; 0.47-#x2013;0.73). The SIRs of Parkinson's disease and epilepsy were not significantly different compared to the general population.
We observe reduced incidence for dementia or Alzheimer's disease in a large cohort of members of two religious communities characterized by lifestyle recommendations. More studies are needed to disentangle the interaction between such lifestyle and other components of the religious belief system.
关于生活方式风险因素和宗教生活对慢性神经疾病影响的了解有限。基督复临安息日会信徒不吸烟、不饮酒、不吃猪肉，许多人坚持蛋奶素食，浸信会则不鼓励过度使用烟酒。
我们调查了一大群丹麦基督复临安息日会信徒和浸信会信徒中四种常见慢性神经疾病（痴呆症、阿尔茨海默病、帕金森病和癫痫）的发病率与丹麦普通人群相比是否存在差异。其中三种疾病是神经退行性疾病，而癫痫可在任何年龄发生。
我们将丹麦宗教团体健康研究中的6532名基督复临安息日会信徒和3720名浸信会信徒与丹麦普通人群中一些主要神经疾病的住院率进行了比较。计算了按性别、年龄和日历时间分层的标准化发病率（SIR）。
两个群体的成员患痴呆症或阿尔茨海默病的标准化发病率均显著降低（基督复临安息日会信徒，0.78；95%可信区间，0.67 - 0.90；浸信会信徒，0.59；0.47 - 0.73）。与普通人群相比，帕金森病和癫痫的标准化发病率没有显著差异。
我们观察到，在两个以生活方式建议为特征的宗教团体的大量成员中，痴呆症或阿尔茨海默病的发病率有所降低。需要更多研究来理清这种生活方式与宗教信仰体系其他组成部分之间的相互作用。
