Institut National de la Santé et de la Recherche Médicale, UMR912 "Health Economy, Social Sciences & Medical Information Processing" (SESSTIM), 232, Boulevard de Sainte-Marguerite, 13009 Marseille, France.
J Clin Epidemiol. 2012 Oct;65(10):1098-106. doi: 10.1016/j.jclinepi.2012.05.010.
To develop a scale for assessing Respondents' Perceptions of Health Research Questionnaires (the REP-HQ Scale) and test this scale psychometrically.
A scale was drawn, based on detailed content analysis of patients' free comments, which were collected prospectively in a 2-year cohort study (n=228). The questionnaire corresponding to this scale was subsequently completed by a cohort of female BRCA1/2 carriers/noncarriers not affected by cancer, who had been followed up for 5 years since test result disclosure (n=246). Principal component analysis, Cronbach's alpha coefficient, and Pearson's correlations were used in the statistical analyses.
The perceived effects that emerged from the respondents' responses were analyzed and classified under the headings: "Useful medical information," "Usefulness of research," and "Labeling intrusion." Cronbach's alpha coefficients on the three dimensions were 0.75, 0.64, and 0.56, respectively. Carriers obtained lower scores than noncarriers on the first dimension (P=0.005) and on the overall score (P=0.002).
The REP-HQ scale is the first generic tool to be developed for assessing participants' perceptions about the effects of health research questionnaires. Further testing is now required to confirm the validity of the findings obtained here by applying this tool in other settings.
开发一种评估受访者对健康研究问卷感知的量表（REP-HQ 量表），并对该量表进行心理测量学测试。
根据前瞻性队列研究（n=228）中收集的患者自由评论的详细内容分析，制定了一个量表。随后，对未受癌症影响的 BRCA1/2 携带者/非携带者女性队列进行了与该量表相对应的问卷调查，这些女性自检测结果披露以来已随访 5 年（n=246）。统计分析采用主成分分析、克朗巴赫α系数和皮尔逊相关系数。
对受访者的回复中出现的感知效果进行了分析，并分为以下标题进行分类：“有用的医学信息”、“研究的有用性”和“标签侵入”。三个维度的克朗巴赫α系数分别为 0.75、0.64 和 0.56。携带者在第一维度（P=0.005）和总体评分（P=0.002）上的得分低于非携带者。
REP-HQ 量表是第一个用于评估参与者对健康研究问卷影响感知的通用工具。现在需要进一步测试，以通过在其他环境中应用该工具来确认这里获得的发现的有效性。
