Oranskiy Sergey P, Yeliseyeva Ludmila N, Tsanaeva Anna V, Zaytseva Nadezhda V
Kuban State Medical University, 4 Sedina Street, Krasnodar 350063, Russian Federation.
Croat Med J. 2012 Aug;53(4):350-6. doi: 10.3325/cmj.2012.53.350.
To investigate differences in body composition and body mass index (BMI) in patients with rheumatoid arthritis (RA) and their correlations with serum production of adiponectin, interleukin-6 (IL-6), and vascular endothelial growth factor (VEGF).
The study included 83 patients (age 53±5 years) with RA treated with methotrexate. We determined their BMI, fat mass, and fat-free mass using bioimpedance analysis, and serum concentrations of adiponectin, VEGF, and IL-6 using immunoassay analysis.
Normal BMI was found in 39 (47%), overweight and obesity in 26 (31%), and underweight in 18 (22%) patients. Concentration of adiponectin was lower in overweight/obese patients than in patients with normal BMI (2.1 [0.8-3.9] μg/mL vs 8.9 (7.2-11.3) μg/mL). In underweight patients, it was moderately increased (12.7 [9.3-14.8] μg/mL) and the correlation between the concentrations of adiponectin and IL-6 was positive (r=0.4; P=0.01). Concentrations of VEGF and IL-6 were increased in all groups with RA. The overweight/obese group showed a negative correlation between the concentrations of adiponectin and VEGF (r=- 0.34; P=0.04), a positive correlation between VEGF concentration and fat mass (r=0.39; P=0.02), and a negative correlation between adiponectin concentration and fat mass (r=- 0.23; P=0.02).
Inflammatory and angiogenesis activation was found in RA patients with all types of body composition, but only in those with obesity and overweight there was a direct antagonism between adiponectin and VEGF. Further research is needed to identify possible regimens of metabolic correction in different variations of body composition.
研究类风湿关节炎（RA）患者的身体成分和体重指数（BMI）差异，以及它们与脂联素、白细胞介素-6（IL-6）和血管内皮生长因子（VEGF）血清水平的相关性。
本研究纳入83例接受甲氨蝶呤治疗的RA患者（年龄53±5岁）。我们采用生物电阻抗分析法测定其BMI、脂肪量和去脂体重，采用免疫分析法测定脂联素、VEGF和IL-6的血清浓度。
39例（47%）患者BMI正常，26例（31%）超重和肥胖，18例（22%）体重过轻。超重/肥胖患者的脂联素浓度低于BMI正常的患者（2.1 [0.8 - 3.9] μg/mL对8.9 [7.2 - 11.3] μg/mL）。体重过轻的患者脂联素浓度中度升高（12.7 [9.3 - 14.8] μg/mL），脂联素浓度与IL-6浓度呈正相关（r = 0.4；P = 0.01）。所有RA组患者VEGF和IL-6浓度均升高。超重/肥胖组脂联素浓度与VEGF浓度呈负相关（r = - 0.34；P = 0.04），VEGF浓度与脂肪量呈正相关（r = 0.39；P = 较），脂联素浓度与脂肪量呈负相关（r = - 0.23；P = 0.02）。
在各种身体成分类型的RA患者中均发现炎症和血管生成激活，但仅在肥胖和超重患者中脂联素与VEGF之间存在直接拮抗作用。需要进一步研究以确定不同身体成分变化情况下可能的代谢纠正方案。
