Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105-3678, USA.
Pediatr Blood Cancer. 2013 Jan;60(1):18-25. doi: 10.1002/pbc.24249. Epub 2012 Aug 21.
Central venous catheters are essential for treatment of cancer and hematologic disorders in children. Central line-associated bloodstream infection (CLABSI) is the most common important complication and can lead to serious sequelae. Conventional antibiotic treatment is often unsuccessful. Ethanol lock therapy (ELT) has been shown to prevent CLABSI in various patient groups and might also be beneficial as adjunctive treatment for active infection. Efficacy and safety have not been adequately studied in the pediatric hematology/oncology population. Catheter occlusion and intraluminal clots have been reported. Routine use of ELT should not be recommended in this population until more data are available.
中心静脉导管是治疗儿童癌症和血液系统疾病的重要手段。中心静脉导管相关血流感染（CLABSI）是最常见的严重并发症，可导致严重的后遗症。传统的抗生素治疗往往无效。乙醇封管疗法（ELT）已被证明可预防各种患者群体中的 CLABSI，并且作为活动性感染的辅助治疗可能也有益。但其在儿科血液学/肿瘤学人群中的疗效和安全性尚未得到充分研究。有报道称导管阻塞和管腔内血栓形成。在更多数据可用之前，不建议在该人群中常规使用 ELT。
