Gholami Ali, Salarilak Shaker, Hejazi Sasan, Khalkhali Hamid Reza
Department of Epidemiology and Biostatistics, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
J Res Health Sci. 2011 Nov 4;11(2):69-76.
Leukemia is the most common cancer in children, accounting for near to half of all childhood cancers. Different risk factors might be effective in the occurrence of this cancer such as parental characteristics. This study was done in West Azarbaijan Province in order to determine the relation between parental characteristics and acute leukemia in children.
This matched case-control study was conducted on children less than 15 years affected by acute leukemia from March 20, 2003 to March 20, 2009. Two control groups were selected, one from hospital and the other from the study population. Cases and controls were matched on age and sex. Logistic regression model was used for data analysis.
This study was done on 130 patients, 108 (83.1%) were affected by Acute Lymphoblastic Leukemia and 22 (16.9%) by Acute Myeloblastic Leuke-mia. Seventy two of the patients were male (55.4%) and 58 were female (44.6%). There was a statistically significant correlation between acute leuke-mia and variables such as mother's education [OR=4.2, 95% CI: 2.42, 7.34], mother's history of using Oral Contraceptive Pills [OR=1.77, 95% CI: 1.05, 2.82] and parental relationship [OR=2.05, 95% CI: 1.30, 3.23].
It seems that some parental characteristics have an important role in etiology of childhood leukemia.
白血病是儿童最常见的癌症，占所有儿童癌症的近一半。不同的风险因素可能对这种癌症的发生有影响，如父母的特征。本研究在西阿塞拜疆省进行，以确定父母特征与儿童急性白血病之间的关系。
这项匹配病例对照研究针对2003年3月20日至2009年3月20日期间患急性白血病的15岁以下儿童进行。选择了两个对照组，一个来自医院，另一个来自研究人群。病例和对照在年龄和性别上进行匹配。采用逻辑回归模型进行数据分析。
本研究共纳入130例患者，其中108例（83.1%）患有急性淋巴细胞白血病，22例（16.9%）患有急性髓细胞白血病。患者中72例为男性（55.4%），58例为女性（44.6%）。急性白血病与母亲教育程度[比值比（OR）=4.2，95%置信区间（CI）：2.42，7.34]、母亲口服避孕药史[OR=1.77，95%CI：1.05，2.82]和父母关系[OR=2.05，95%CI：1.30，3.23]等变量之间存在统计学显著相关性。
似乎一些父母特征在儿童白血病的病因学中具有重要作用。
