Liao Wei-Hsuan, Wei Kuo-Liang, Wu Cheng-Shyong
Division of Gastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital at Chiayi, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Chang Gung Med J. 2012 Jul-Aug;35(4):354-9. doi: 10.4103/2319-4170.106134.
Eosinophilic gastroenteritis is a rare gastrointestinal disorder characterized by nonspecific gastrointestinal symptoms, peripheral eosinophilia, and eosinophilic infiltration of the intestinal wall. The disorder is classified into mucosal, muscular, and subserosal types, depending on the depth of eosinophilic infiltration within the gastrointestinal wall, and the clinical picture varies accordingly. Subserosal disease, which is complicated by ascites, usually results in the most severe clinical form of eosinophilic gastroenteritis and mandates early corticosteroid therapy. In such cases, a favorable outcome can be achieved after a short course of corticosteroids. We present a rare case in a 43 year-old man in whom eosinophilic gastroenteritis spontaneously resolved without any medical treatment. After reviewing the literature and excluding secondary causes of eosinophilic gastroenteritis, we concluded that this may be the first reported case of spontaneous resolution of primary subserosal eosinophilic gastroenteritis.
嗜酸性胃肠炎是一种罕见的胃肠道疾病，其特征为非特异性胃肠道症状、外周血嗜酸性粒细胞增多以及肠壁嗜酸性粒细胞浸润。根据嗜酸性粒细胞在胃肠道壁内浸润的深度，该疾病可分为黏膜型、肌层型和浆膜下层型，临床表现也相应有所不同。伴有腹水的浆膜下层疾病通常导致嗜酸性胃肠炎最严重的临床形式，需要早期使用皮质类固醇治疗。在这种情况下，短期使用皮质类固醇后可取得良好疗效。我们报告一例罕见病例，一名43岁男性的嗜酸性胃肠炎未经任何治疗而自行缓解。在查阅文献并排除嗜酸性胃肠炎的继发原因后，我们得出结论，这可能是首例原发性浆膜下层嗜酸性胃肠炎自发缓解的报道病例。
