Martino G V, Grimaldi L M, Franciotta D M, Piccolo G, Brustia R, Minali L, Melzi d'Eril G V
Neurology Clinic IV, Milan University, IRCCS H. San Raffaele, Italy.
Acta Neurol Scand. 1990 Dec;82(6):364-7. doi: 10.1111/j.1600-0404.1990.tb03318.x.
We report a case of herpetic brainstem encephalitis (HBE) retrospectively diagnosed in adult patient. Conventional immunovirological studies failed to disclose the etiology of this patient's affection. An isoelectric focusing-antigen overlay (IEF-O) technique showed that the target of one of the four cerebrospinal fluid oligoclonal bands was herpes simplex virus (HSV)-1 glycoprotein B, indicating a specific anti-HSV immunoresponse restricted to the CNS. IEF-O may represent a useful support for in vivo diagnosis of HBE.
我们报告一例在成年患者中回顾性诊断出的疱疹性脑干脑炎（HBE）。传统的免疫病毒学研究未能揭示该患者病情的病因。等电聚焦-抗原覆盖（IEF-O）技术显示，四个脑脊液寡克隆带之一的靶点是单纯疱疹病毒（HSV）-1糖蛋白B，表明存在局限于中枢神经系统的特异性抗HSV免疫反应。IEF-O可能对HBE的体内诊断有帮助。
