Department of Family Medicine, Biostatistics, and Obstetrics and Gynecology and the School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Obstet Gynecol. 2012 Jul;120(1):145-51. doi: 10.1097/AOG.0b013e31825957cf.
To estimate the relationship among the presence of vulvodynia, fibromyalgia, interstitial cystitis, and irritable bowel syndrome.
Validated questionnaire-based screening tests for the four pain conditions were completed by women with and without vulvodynia who were participating in the Michigan Woman to Woman Health Study, a longitudinal population-based survey in southeastern Michigan. Weighted population-based estimates of the prevalence and characteristics of participants with these chronic comorbid pain conditions were calculated using regression analyses.
Of 1,940 women who completed the survey containing all four screening tests, 1,890 (97.4%) answered all screening questions and were included. The prevalences of the screening-based diagnoses ranged from 7.5% (95% confidence interval [CI] 6.2-9.0) for interstitial cystitis, 8.7% (95% CI 7.3-10.4) for vulvodynia, 9.4% (95% CI 8.1-11.0) for irritable bowel syndrome, to 11.8% (95% CI 10.1-13.7) for fibromyalgia with 27.1% screening positive for multiple conditions. The presence of vulvodynia was associated with the presence of each of the other comorbid pain conditions (P<.001, odds ratio 2.3-3.3). Demographic risk factors for each condition varied. Increasing age was not associated with greater numbers of comorbid conditions, and only low socioeconomic status was associated with having multiple comorbid conditions concurrently.
Chronic pain conditions are common, and a subgroup of women with vulvodynia is more likely than those without vulvodynia to have one or more of the three other chronic pain conditions evaluated.
评估外阴痛、纤维肌痛、间质性膀胱炎和肠易激综合征之间的关系。
在密歇根州妇女健康纵向人群调查中，患有或不患有外阴痛的女性完成了四项疼痛状况的基于问卷调查的有效筛查测试。采用回归分析计算这些慢性共病疼痛状况的参与者的加权人群患病率和特征。
在完成包含所有四项筛查测试的调查的 1940 名女性中，有 1890 名（97.4%）回答了所有筛查问题并被纳入。基于筛查的诊断患病率范围从间质性膀胱炎的 7.5%（95%置信区间[CI]6.2-9.0）、外阴痛的 8.7%（95% CI 7.3-10.4）、肠易激综合征的 9.4%（95% CI 8.1-11.0）到纤维肌痛的 11.8%（95% CI 10.1-13.7），27.1%的人筛查呈多种病症阳性。外阴痛的存在与其他共病疼痛状况的存在相关（P<.001，比值比 2.3-3.3）。每种疾病的人口统计学风险因素不同。年龄增加与共病数量增加无关，只有低社会经济地位与同时患有多种共病相关。
慢性疼痛状况很常见，患有外阴痛的女性亚组比不患有外阴痛的女性更有可能患有评估的三种其他慢性疼痛状况之一或多种。
