Center for Computational Imaging and Simulation Technologies in Biomedicine (CISTIB), Information and Communication Technologies Department, Universitat Pompeu Fabra, Barcelona, Spain.
J Neurointerv Surg. 2013 Nov;5 Suppl 3(0 3):iii33-7. doi: 10.1136/neurintsurg-2012-010456. Epub 2012 Aug 21.
Endovascular coiling is often performed by first placing coils along the aneurysm wall to create a frame and then by filling up the aneurysm core. However, little attention has been paid to quantifying this filling strategy and to see how it changes for different packing densities. The purpose of this work is to analyze and quantify endovascular coil distribution inside aneurysms based on serial histological images of experimental aneurysms.
Seventeen histological images from 10 elastase-induced saccular aneurysms in rabbits treated with coils were studied. In-slice coil density, defined as the area taken up by coil winds, was calculated on each histological image. Images were analyzed by partitioning the aneurysm along its longitudinal and radial axes. Coil distribution was quantified by measuring and comparing the in-slice coil density of each partition.
Mean total in-slice coil density was 22.0 ± 6.2% (range 10.1-30.2%). The density was non-significantly different (p = 0.465) along the longitudinal axis. A significant difference (p < 0.001) between peripheral and core densities was found. Additionally, the peripheral-core density ratio was observed to be inversely proportional to the total in-slice coil density (R(2)=0.57, p <0.001). This ratio was near unity for high in-slice coil density (around 30%).
These findings demonstrate and confirm that coils tend to be located near the aneurysm periphery when few are inserted. However, when more coils are added, the radial distribution becomes more homogeneous. Coils are homogeneously distributed along the longitudinal axis.
血管内线圈填塞通常是先沿着动脉瘤壁放置线圈以形成框架，然后再填充动脉瘤核心。然而，对于这种填塞策略的量化以及不同填塞密度下的变化，关注较少。本研究旨在基于实验性动脉瘤的连续组织学图像分析和量化血管内线圈在动脉瘤内的分布。
研究了 10 只兔弹性蛋白酶诱导的囊状动脉瘤中 17 个接受线圈治疗的组织学图像。在每个组织学图像上计算了切片内线圈密度，定义为线圈绕组所占的面积。通过沿动脉瘤的纵轴和横轴对图像进行分区，分析图像。通过测量和比较每个分区的切片内线圈密度来量化线圈分布。
平均总切片内线圈密度为 22.0±6.2%（范围 10.1-30.2%）。沿纵轴的密度无统计学差异（p=0.465）。发现外周和核心密度之间存在显著差异（p<0.001）。此外，还观察到外周-核心密度比与总切片内线圈密度呈反比（R²=0.57，p<0.001）。当切片内线圈密度较高（约 30%）时，该比值接近 1。
这些发现表明并证实了当插入较少的线圈时，线圈倾向于位于动脉瘤的外周。然而，当添加更多的线圈时，径向分布变得更加均匀。线圈在纵轴上均匀分布。
