脊椎动物轴 Specification 中的 Wnt 信号传导。
Wnt signaling in vertebrate axis specification.
机构信息
Division of Cancer Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan.
出版信息
Cold Spring Harb Perspect Biol. 2013 Jan 1;5(1):a007955. doi: 10.1101/cshperspect.a007955.
Abstract
The Wnt pathway is a major embryonic signaling pathway that controls cell proliferation, cell fate, and body-axis determination in vertebrate embryos. Soon after egg fertilization, Wnt pathway components play a role in microtubule-dependent dorsoventral axis specification. Later in embryogenesis, another conserved function of the pathway is to specify the anteroposterior axis. The dual role of Wnt signaling in Xenopus and zebrafish embryos is regulated at different developmental stages by distinct sets of Wnt target genes. This review highlights recent progress in the discrimination of different signaling branches and the identification of specific pathway targets during vertebrate axial development.
摘要
Wnt 通路是一个主要的胚胎信号通路，它控制着脊椎动物胚胎中的细胞增殖、细胞命运和体轴决定。在卵子受精后不久，Wnt 通路成分在微管依赖性背腹轴特化中发挥作用。在胚胎发生的后期，该途径的另一个保守功能是特化前-后轴。Wnt 信号在非洲爪蟾和斑马鱼胚胎中的双重作用是通过不同的 Wnt 靶基因在不同的发育阶段调节的。这篇综述强调了在脊椎动物轴向发育过程中区分不同信号分支和鉴定特定途径靶标的最新进展。
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