1Department of Cardiology, Xinghua People's Hospital, Xinghua, China.
Clin Appl Thromb Hemost. 2013 Nov-Dec;19(6):673-8. doi: 10.1177/1076029612457706. Epub 2012 Aug 21.
Atrial fibrillation (AF) not only is an independent risk factor for death but also confers significant risk of morbidity from stroke associated with left atrial thrombus. The association of interleukin 6 (IL-6) polymorphism with thrombus in AF has not been investigated before. We carried out a case-control study in Han Chinese. The IL-6 -634C/G genotypes of 31 patients with thrombus and 45 patients without thrombus were detected by polymerase chain reaction and restriction fragment length polymorphism. The frequencies of the IL-6 genotypes (CC, CG, and GG) were 29.03%, 54.54%, and 16.13% for the patients with thrombus, and 55.56%, 40.00%, and 4.44% for the patients without thrombus, respectively (P = .0391). Compared with the CC genotype, the G allele carriers (CG + GG) had a 2.79-fold increased risk of thrombus or severe spontaneous echocontrast (SEC). These results suggest that IL-6 -634C/G polymorphism is associated with thrombus and severe SEC, and the G allele is an independent risk for thrombus and severe SEC in Han Chinese patients with AF.
心房颤动（AF）不仅是死亡的独立危险因素，而且与左心房血栓相关的中风发病率也有显著风险。白细胞介素 6（IL-6）多态性与 AF 血栓之间的关联以前尚未被研究过。我们在中国汉族人群中进行了一项病例对照研究。通过聚合酶链反应和限制性片段长度多态性检测了 31 例血栓患者和 45 例无血栓患者的 IL-6 -634C / G 基因型。血栓患者的 IL-6 基因型（CC、CG 和 GG）的频率分别为 29.03%、54.54%和 16.13%，无血栓患者的频率分别为 55.56%、40.00%和 4.44%（P =.0391）。与 CC 基因型相比，G 等位基因携带者（CG + GG）发生血栓或严重自发性回声对比（SEC）的风险增加了 2.79 倍。这些结果表明，IL-6 -634C / G 多态性与血栓和严重 SEC 相关，G 等位基因是汉族 AF 患者血栓和严重 SEC 的独立危险因素。
