Department of Geraeology, Affiliated Hospital of Nantong University, PR China.
J Interferon Cytokine Res. 2012 Nov;32(11):542-7. doi: 10.1089/jir.2012.0033. Epub 2012 Aug 27.
There is an accumulating body of evidence indicating a strong association between inflammation and the pathogenesis of atrial fibrillation (AF). Interleukin-6 (IL-6) is a pleiotropic cytokine, functions as a mediator of inflammatory response, and has both proinflammatory and anti-inflammatory properties. The aim of the present study was to investigate the association of the -634C/G polymorphism of the IL-6 gene with AF in elderly Han Chinese patients with essential hypertension (EH). A total of 169 elderly patients with EH were eligible for this study. Patients with AF (n=75) were allocated to the AF group, and 94 subjects without AF to the control group. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to assess the genotype frequencies. The distribution of the IL-6 -634C/G genotypes (CC, CG, and GG) was 67.02%, 30.85%, and 2.13% in the controls, and 50.67%, 40.00%, and 9.33% in AF subjects, respectively (P=0.0312). The frequency of the G allele in the AF group was significantly higher than that in the control group (29.33% vs. 17.55%, P=0.0103). Compared with the CC and CG genotypes, the GG homozygote had a 4.7353-fold increased risk of AF [95% confidence interval (CI)=0.9537-23.5116, P=0.0382]. These findings suggest that the IL-6 -634C/G polymorphism is associated with AF, and the G allele has increased risk of AF in elderly Han Chinese patients with EH.
有越来越多的证据表明，炎症与心房颤动（AF）的发病机制之间存在密切关联。白细胞介素-6（IL-6）是一种多效细胞因子，作为炎症反应的介质，具有促炎和抗炎特性。本研究旨在探讨白细胞介素-6 基因-634C/G 多态性与老年汉族原发性高血压（EH）患者 AF 的关系。共有 169 名老年 EH 患者符合本研究条件。AF 患者（n=75）被分配到 AF 组，94 名无 AF 患者被分配到对照组。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术评估基因型频率。IL-6-634C/G 基因型（CC、CG 和 GG）在对照组中的分布分别为 67.02%、30.85%和 2.13%，在 AF 组中的分布分别为 50.67%、40.00%和 9.33%（P=0.0312）。AF 组 G 等位基因的频率明显高于对照组（29.33%比 17.55%，P=0.0103）。与 CC 和 CG 基因型相比，GG 纯合子发生 AF 的风险增加了 4.7353 倍[95%置信区间（CI）=0.9537-23.5116，P=0.0382]。这些发现表明，IL-6-634C/G 多态性与 AF 相关，G 等位基因使老年汉族 EH 患者发生 AF 的风险增加 4.7353 倍。
