HIF-1alpha 基因多态性影响淋巴结转移的发生，并可能影响声门型喉鳞状细胞癌的肿瘤大小。
Polymorphisms in HIF-1alpha affect presence of lymph node metastasis and can influence tumor size in squamous-cell carcinoma of the glottic larynx.
机构信息
Departamento de Otorrinolaringología, Hospital Universitario de La Princesa, Universidad Autónoma de Madrid, 4ª Planta, C/Diego de Leon, 62, 28006, Madrid, Spain.
出版信息
Clin Transl Oncol. 2013 May;15(5):358-63. doi: 10.1007/s12094-012-0930-z. Epub 2012 Aug 23.
BACKGROUND
HIF-1alpha plays a key role in the development and progression of cancer. Its polymorphic variants C1772T and G1790A have been associated with greater susceptibility to cancer and increased tumor progression.
METHODS
We determined the distribution of these polymorphisms among 121 patients with glottic cancer and 154 healthy volunteers by PCR-RFLP. We also analyzed the relationship between the presence of these polymorphisms and various clinicopathologic variables.
RESULTS
Advanced tumors (T3-T4) were associated with the TT variant (p = 0.036), which was present in 75 % of T4 tumors (p = 0.008). Among patients with nodal metastasis (N+), 41.7 and 22 % were carrying the TT and GA variants, respectively, compared with 9.4 and 2 % of the patients with no metastasis (N0), (p = 0.006 and p = 0.032).
CONCLUSIONS
The presence of the TT and GA variants were associated with lymph node metastasis, while the presence of the TT variant can be associated with larger tumor size.
背景
HIF-1α 在癌症的发生和发展中起着关键作用。其多态性变体 C1772T 和 G1790A 与癌症易感性增加和肿瘤进展增加有关。
方法
我们通过 PCR-RFLP 法在 121 例声门癌患者和 154 名健康志愿者中确定了这些多态性的分布。我们还分析了这些多态性的存在与各种临床病理变量之间的关系。
结果
晚期肿瘤（T3-T4）与 TT 变体相关（p = 0.036），T4 肿瘤中存在 TT 变体的比例为 75%（p = 0.008）。在有淋巴结转移（N+）的患者中，携带 TT 和 GA 变体的患者分别为 41.7%和 22%，而无转移（N0）的患者分别为 9.4%和 2%（p = 0.006 和 p = 0.032）。
结论
TT 和 GA 变体的存在与淋巴结转移有关，而 TT 变体的存在可能与肿瘤体积较大有关。
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