Zhu Jing, Cheng Xiang, Xie Rongkai, Chen Zhengqiong, Li Youfei, Lin Guilan, Liu Jianmei, Yang Ying
Department of Gynaecology and Obstetrics, Xinqiao Hospital, Third Military Medical University Chongqing 400037, China.
Int J Clin Exp Pathol. 2014 Aug 15;7(9):6085-90. eCollection 2014.
Hypoxia-inducible factor-1 alpha (HIF-1α) P582S polymorphism has been reported to increase transactivation capacity of HIF-1α, which is prone to tumorigenesis. Several published case-control studies on the association between P582S polymorphism and cervical cancer have shown mixed results. In this study, we chose to perform a meta-analysis to assess the association.
METHODOLOGY/PRINCIPAL FINDINGS: We conducted a meta-analysis consisting of four studies with a total of 846 cases and 991 controls. All data were collected and overall comparison was performed among all subjects. Using the fixed effects model, the homozygous and the recessive models showed a significant increase in the risk of cervical cancer (the pooled OR=6.32, 95% CI=2.28-17.55, Phet=0.348; the pooled OR=5.86, 95% CI=2.13-16.11, Phet=0.394 respectively). Publication bias was not significantly indicated in this analysis.
This meta-analysis demonstrates that HIF-1α P582S polymorphism may be associated with the risk of cervical cancer.
据报道，缺氧诱导因子-1α（HIF-1α）P582S多态性可增加HIF-1α的反式激活能力，这易于引发肿瘤发生。几项已发表的关于P582S多态性与宫颈癌之间关联的病例对照研究结果不一。在本研究中，我们选择进行一项荟萃分析以评估这种关联。
方法/主要发现：我们进行了一项荟萃分析，纳入四项研究，共846例病例和991例对照。收集了所有数据并在所有受试者中进行了总体比较。使用固定效应模型，纯合子模型和隐性模型显示宫颈癌风险显著增加（合并比值比=6.32，95%置信区间=2.28 - 17.55，异质性P值=0.348；合并比值比=5.86，95%置信区间=2.13 - 16.11，异质性P值分别为0.394）。该分析未显示出显著的发表偏倚。
这项荟萃分析表明，HIF-1α P582S多态性可能与宫颈癌风险相关。
