Belverud Shawn A, Mogilner Alon Y, Schulder Michael
North Shore University Hospital Department of Neurosurgery, Harvey Cushing Institute for Neuroscience, Manhasset, NY, USA.
Local Reg Anesth. 2010;3:125-8. doi: 10.2147/LRA.S7841. Epub 2010 Oct 11.
Direct central nervous system (CNS) analgesic delivery is a useful option when more traditional means of dealing with chronic pain fail. Solutions containing local anesthetic have been effective in certain disease states, particularly in patients suffering from intractable head and neck pain. This review discusses historical aspects of CNS drug delivery and the role of intrathecal bupivacaine-containing solutions in refractory head and neck pain patients.
当更传统的慢性疼痛治疗方法无效时,直接进行中枢神经系统(CNS)镇痛给药是一种有用的选择。含局部麻醉剂的溶液在某些疾病状态下已显示出有效性,尤其是在患有顽固性头颈疼痛的患者中。本文综述了中枢神经系统药物递送的历史背景以及含布比卡因的鞘内溶液在难治性头颈疼痛患者中的作用。