Lai Jin-Shei, Bode Rita, Wee Hwee-Lin, Eton David, Cella David
Department of Medical Social Sciences.
Patient Relat Outcome Meas. 2010 Jul;1:51-6. doi: 10.2147/prom.s10658. Epub 2010 Jun 18.
We aimed to validate a more rapid, yet reliable means of assessing physical function (PF) for patients with prostate cancer. The sample included 128 prostate cancer patients recruited from urology and general oncology clinics at two Chicago-area hospitals. The main outcome measures were: A 36-item PF item bank that included a 5-item short form (BriefPF) and the 10-item PF subscale (PF-10) from the Medical Outcomes Study SF-36. Validity, information function, and relative precision (calculated using Rasch analysis and raw scores) of the BriefPF were compared to the PF-10 and the full PF item bank. We found that the BriefPF and PF-10 were strongly correlated (r = 0.85) with the PF bank, and all three scales differentiated patients according to performance status (F(PF bank)(2,124) = 32.51 P < 0.001, F(PF-10)(2,121) = 27.35 P < 0.001, F(BriefPF) (2,123) = 38.40 P < 0.001). BriefPF has excellent precision relative to the PF-10 in measuring patients with different performance status levels. The Rasch-based information function indicated that the BriefPF was more informative than PF-10 in measuring moderate to higher functioning patients. Hence, the BriefPF offers a parsimonious and precise measure of PF for use among men with prostate cancer, and may aid in the timely inclusion of patient-reported outcomes in treatment decision-making.
我们旨在验证一种更快速且可靠的方法,用于评估前列腺癌患者的身体功能(PF)。样本包括从芝加哥地区两家医院的泌尿外科和普通肿瘤诊所招募的128名前列腺癌患者。主要结局指标为:一个包含36个项目的PF题库,其中包括一个5项简短形式(BriefPF)以及医学结局研究简表36(SF-36)中的10项PF子量表(PF-10)。将BriefPF的效度、信息功能和相对精度(使用拉施分析和原始分数计算)与PF-10和完整的PF题库进行比较。我们发现BriefPF和PF-10与PF题库高度相关(r = 0.85),并且所有三个量表都根据患者的表现状态区分了患者(F(PF题库)(2,124)= 32.51,P < 0.001;F(PF-10)(2,121)= 27.35,P < 0.001;F(BriefPF)(2,123)= 38.40,P < 0.001)。在测量不同表现状态水平的患者时,BriefPF相对于PF-10具有出色的精度。基于拉施的信息功能表明,在测量中度至较高功能的患者时,BriefPF比PF-10提供的信息更多。因此,BriefPF为前列腺癌男性患者提供了一种简洁而精确的PF测量方法,可能有助于在治疗决策中及时纳入患者报告的结局。