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血清尿酸作为充血性心力衰竭肾功能不全的指标。

Serum uric acid as an index of impaired renal function in congestive heart failure.

机构信息

Emergency Department, The First Hospital of Hebei Medical University, Hebei Medical University, 89 Donggang Road, Shijiazhuang 050031, Hebei Province, China.

出版信息

J Geriatr Cardiol. 2012 Jun;9(2):137-42. doi: 10.3724/SP.J.1263.2011.11281.

DOI:10.3724/SP.J.1263.2011.11281
PMID:22916059
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3418902/
Abstract

BACKGROUND

Hyperuricemia is frequently present in patients with heart failure. Many pathological conditions, such as tissue ischemia, renal function impairment, cardiac function impairment, metabolic syndrome, and inflammatory status, may impact uric acid (UA) metabolism. This study was to assess their potential relations to UA metabolism in heart failure.

METHODS

We retrospectively assessed clinical characteristics, echocardiological, renal, metabolic and inflammatory variables selected on the basis of previous evidence of their involvement in cardiovascular diseases and UA metabolism in a large cohort of randomly selected adults with congestive heart failure (n = 553). By clustering of indices, those variables were explored using factor analysis.

RESULTS

In factor analysis, serum uric acid (SUA) formed part of a principal cluster of renal functional variables which included serum creatinine (SCr) and blood urea nitrogen (BUN). Univariate correlation coefficients between variables of patients with congestive heart failure showed that the strongest correlations for SUA were with BUN (r = 0.48, P < 0.001) and SCr (r = 0.47, P < 0.001).

CONCLUSIONS

There was an inverse relationship between SUA levels and measures of renal function in patients with congestive heart failure. The strong correlation between SUA and SCr and BUN levels suggests that elevated SUA concentrations reflect an impairment of renal function in heart failure.

摘要

背景

心力衰竭患者常伴有高尿酸血症。许多病理状况，如组织缺血、肾功能损害、心功能损害、代谢综合征和炎症状态，可能会影响尿酸（UA）代谢。本研究旨在评估它们与心力衰竭患者 UA 代谢之间的潜在关系。

方法

我们回顾性评估了临床特征、超声心动图、肾功能、代谢和炎症变量，这些变量是基于先前涉及心血管疾病和 UA 代谢的证据选择的，入选了随机选择的患有充血性心力衰竭的大量成年患者（n=553）。通过对指数进行聚类，使用因子分析对这些变量进行了探索。

结果

在因子分析中，血清尿酸（SUA）是肾功能变量的主要聚类之一，其中包括血清肌酐（SCr）和血尿素氮（BUN）。充血性心力衰竭患者的变量之间的单变量相关系数表明，SUA 与 BUN（r=0.48，P<0.001）和 SCr（r=0.47，P<0.001）的相关性最强。

结论

心力衰竭患者的 SUA 水平与肾功能指标呈负相关。SUA 与 SCr 和 BUN 水平之间的强相关性表明，SUA 浓度升高反映了心力衰竭患者肾功能受损。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a09e/3418902/debad39fee77/jgc-09-02-137-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a09e/3418902/debad39fee77/jgc-09-02-137-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a09e/3418902/debad39fee77/jgc-09-02-137-g001.jpg

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