Yu Qian, Shen Hsi-Che, Hu Yi-Chun, Chen Yu-Fen, Tung Tao-Hsin
Department of Foot Science, Fu-Jen Catholic University, New Taipei City, Taiwan.
Department of Pharmacy, School of Biomedicine Sciences, Huaqiao University, Quanzhou, China.
Arch Rheumatol. 2017 Apr 13;32(2):149-157. doi: 10.5606/ArchRheumatol.2017.6075. eCollection 2017 Jun.
This study aims to explore the potential condition-related sex differences to understand the overall pathogenesis of hyperuricemia among the elderly agricultural and fishing population in Taipei, Taiwan.
This study included 4,372 healthy elderly agricultural and fishing professionals (2,766 males, 1,606 females; mean age 74.4±6.6 years; range 65.0 to 90.3 years) voluntarily admitted to a teaching hospital in Taipei, Taiwan for physical exams in 2010. Their fasting blood samples were drawn through venipuncture, and they were administered a structured questionnaire by clinical nurses.
The overall prevalence of hyperuricemia was 30.4%, which increased significantly with increasing age (p<0.001). The prevalence was similar in males (30.2%) and females (30.6%) (p=0.78). Age, obesity, type 2 diabetes, hypercholesterolemia, hypertriglyceridemia as well as low high- density lipoprotein and high blood urea nitrogen, creatinine, and alanine amino transferase levels were significantly associated with hyperuricemia. Hypercholesterolemia (odds ratio [OR]=1.26, 95% confidence interval [CI]: 1.05-2.50) and high creatinine levels (OR=3.75, 95% CI: 2.64-5.33) were significantly associated with hyperuricemia in males, whereas type 2 diabetes (OR=1.54, 95% CI: 1.22-1.93) and high alanine amino transferase levels (OR=1.79, 95% CI: 1.31-2.43) were significantly associated with hyperuricemia in females. Hyperuricemia disparity among age groups was also revealed.
Several sex-related differences with regard to factors including age, obesity, type 2 diabetes, hypercholesterolemia, hypertriglyceridemia, low high-density lipoprotein, high blood urea nitrogen, creatinine, and alanine amino transferase levels were indicated in the prevalence of hyperuricemia in this specific elderly population.
本研究旨在探讨与病情相关的潜在性别差异，以了解台湾台北地区老年农业和渔业人群高尿酸血症的总体发病机制。
本研究纳入了2010年自愿到台湾台北一家教学医院进行体检的4372名健康老年农业和渔业从业者（男性2766名，女性1606名；平均年龄74.4±6.6岁；年龄范围65.0至90.3岁）。通过静脉穿刺采集他们的空腹血样，并由临床护士对他们进行结构化问卷调查。
高尿酸血症的总体患病率为30.4%，随年龄增长显著增加（p<0.001）。男性（30.2%）和女性（30.6%）的患病率相似（p=0.78）。年龄、肥胖、2型糖尿病、高胆固醇血症、高甘油三酯血症以及低高密度脂蛋白和高血尿素氮、肌酐和丙氨酸转氨酶水平与高尿酸血症显著相关。高胆固醇血症（比值比[OR]=1.26，95%置信区间[CI]：1.05 - 2.50）和高肌酐水平（OR=3.75，95% CI：2.64 - 5.33）与男性高尿酸血症显著相关，而2型糖尿病（OR=1.54，95% CI：1.22 - 1.93）和高丙氨酸转氨酶水平（OR=1.79，95% CI：1.31 - 2.43）与女性高尿酸血症显著相关。还揭示了不同年龄组之间高尿酸血症的差异。
在这一特定老年人群的高尿酸血症患病率方面，显示出在年龄、肥胖、2型糖尿病、高胆固醇血症、高甘油三酯血症、低高密度脂蛋白、高血尿素氮、肌酐和丙氨酸转氨酶水平等因素上存在一些与性别相关的差异。
