Kusmiesz H, Shelton S, Brown O, Manning S, Nelson J D
Department of Otorhinolaryngology University of Texas, Southwestern Medical Center, Dallas 75235.
Antimicrob Agents Chemother. 1990 Oct;34(10):2030-1. doi: 10.1128/AAC.34.10.2030.
Loracarbef concentrations in plasma and middle ear fluid (MEF) were measured in specimens obtained approximately 2 h after doses of 7.5 or 15 mg/kg. The mean +/- standard deviation concentrations in MEF were 2.0 +/- 2.6 mg/liter (48% of the concentration in plasma) after the smaller dose and 3.9 +/- 2.6 mg/liter (42% of the concentration in plasma) after the larger dose. With the larger dose, the concentrations in MEF were greater than the MIC for 90% of strains of the usual pathogens of acute otitis media tested in 16 of 17 specimens.
在给予7.5或15mg/kg剂量后约2小时采集的样本中，测定了血浆和中耳液（MEF）中的氯碳头孢浓度。较小剂量后，MEF中的平均浓度±标准差为2.0±2.6mg/升（血浆浓度的48%），较大剂量后为3.9±2.6mg/升（血浆浓度的42%）。使用较大剂量时，在17个样本中的16个样本中，MEF中的浓度高于所检测的16种急性中耳炎常见病原体90%菌株的最低抑菌浓度（MIC）。
