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来自……根部的具有抗炎和保肝作用的环烯醚萜苷 。 （原文句子不完整，翻译只能到这里）

Anti-inflammatory and Hepatoprotective Iridoid Glycosides from the Roots of .

作者信息

Tran Huynh Quoc-Dung, Phan Thuy-Tien Thi, Liu Ta-Wei, Nguyen Thanh-Vu, Duong Truc-Ly Thi, Hsu Su-Jung, Chu Man-Hsiu, Wang Yun-Han, Nguyen Bui Bien-Thuy, Nguyen Dang-Khoa, Vo Thanh-Hoa, Lee Ching-Kuo

机构信息

Ph.D. Program in Clinical Drug Development of Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.

Institute of Pharmaceutical Education and Research, Binh Duong University, Thu Dau Mot 820000, Binh Duong, Vietnam.

出版信息

J Nat Prod. 2025 Feb 28;88(2):577-592. doi: 10.1021/acs.jnatprod.4c01484. Epub 2025 Feb 13.

DOI:10.1021/acs.jnatprod.4c01484
PMID:39947889
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11877508/
Abstract

Ten previously undescribed iridoid glycosides (-), including monoiridoids, hybrid iridoid-alkaloids, bis-iridoids, noriridoid-iridoid dimers, and tetramers, were isolated from the roots of Merr. Structural elucidation revealed unique sugar chains not previously observed for iridoids and complex tetrameric configurations that are rare in nature. Compounds , , and demonstrated significant anti-inflammatory effects, with IC values ranging from 6.13 to 13.0 μM, and compounds , , and - showed notable hepatoprotective activity in HepG2 cells. Additionally, structure-activity relationship (SAR) analysis on anti-inflammatory effects was also conducted. This study enriches the structural database of iridoids, particularly complex derivatives, and highlights their therapeutic potential in addressing inflammation-related and liver diseases.

摘要

从Merr.的根部分离出了十种先前未描述的环烯醚萜苷（-），包括单环烯醚萜、杂环烯醚萜 - 生物碱、双环烯醚萜、去甲环烯醚萜 - 环烯醚萜二聚体和四聚体。结构解析揭示了环烯醚萜类化合物以前未观察到的独特糖链以及自然界中罕见的复杂四聚体构型。化合物 、 和 表现出显著的抗炎作用，IC值范围为6.13至13.0 μM，化合物 、 和 - 在HepG2细胞中显示出显著的肝保护活性。此外，还进行了抗炎作用的构效关系（SAR）分析。本研究丰富了环烯醚萜类化合物的结构数据库，特别是复杂衍生物，并突出了它们在治疗炎症相关疾病和肝脏疾病方面的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ff/11877508/0917a9dd98ab/np4c01484_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ff/11877508/36c8ccf52a16/np4c01484_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ff/11877508/b27578b9d01f/np4c01484_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ff/11877508/9624e14c14fc/np4c01484_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ff/11877508/0917a9dd98ab/np4c01484_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ff/11877508/36c8ccf52a16/np4c01484_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ff/11877508/b27578b9d01f/np4c01484_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ff/11877508/9624e14c14fc/np4c01484_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ff/11877508/0917a9dd98ab/np4c01484_0005.jpg

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Inflammation in Health and Disease: New Insights and Therapeutic Avenues.
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