裸花紫珠叶中的两种新环烯醚萜苷。
Two new iridoid glycosides from the leaves of Callicarpa nudiflora.
作者信息
Wang Jie, Fu Hui-Zheng, Luo Yue-Hua, Ma Yuan-Yu, Huang Bo, Ma Shuang-Cheng
机构信息
a Jiangxi Provincial Institute for Drug Control, Jiangxi Provincial Engineering Research Center for Drug and Medical Device Quality , Nanchang 330029 , China.
b College of Pharmacy, Pharmaceutical Department of Nanchang University , Nanchang 330006 , China.
出版信息
J Asian Nat Prod Res. 2018 Mar;20(3):242-248. doi: 10.1080/10286020.2017.1323884. Epub 2017 May 24.
Two new iridoid glycosides, callicoside C (1) and callicoside D (2), together with three known compounds (3-5), were isolated from the leaves of Callicarpa nudiflora. Their structures were established by 1D and 2D NMR spectroscopy and mass spectrometry. In an in vitro bioassay, compound 1 showed pronounced hepatoprotective activity against d-galactosamine-induced toxicity in WB-F344 rat hepatic epithelial stem-like cells.
从裸花紫珠叶中分离得到两个新的环烯醚萜苷，callicoside C（1）和callicoside D（2），以及三个已知化合物（3 - 5）。通过一维和二维核磁共振光谱及质谱确定了它们的结构。在体外生物测定中，化合物1对d - 半乳糖胺诱导的WB - F344大鼠肝上皮干细胞样细胞毒性表现出显著的肝保护活性。
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