Starr S E, Tolpin M D, Friedman H M, Paucker K, Plotkin S A
J Infect Dis. 1979 Oct;140(4):500-5. doi: 10.1093/infdis/140.4.500.
Cell-mediated immunity to cytomegalovirus (CMV) was determined in congenitally infected children and their mothers by use of assays for CMV-specific lymphocyte blastogenesis and interferon production. Six viruric children responded poorly in both assays. Two older nonviruric children responded in the blastogenesis assay, and lymphocytes from one of them produced interferon. Mothers of older children usually responded in the blastogenesis assay, but only one of them produced interferon. Mothers whose infected infants were younger than nine months of age responded poorly in both assays, while control seropositive postpartum women generally responded normally. The cell-mediated immune defects detected in this study may play a role in the pathogenesis of congenital CMV infection.
通过检测巨细胞病毒（CMV）特异性淋巴细胞增殖和干扰素产生，对先天性感染的儿童及其母亲的细胞介导免疫进行了测定。6名病毒血症儿童在两种检测中反应均较差。2名年龄较大的非病毒血症儿童在增殖检测中有反应，其中1名儿童的淋巴细胞产生了干扰素。年龄较大儿童的母亲在增殖检测中通常有反应，但只有1名母亲产生了干扰素。其感染婴儿年龄小于9个月的母亲在两种检测中反应均较差，而对照血清反应阳性的产后妇女通常反应正常。本研究中检测到的细胞介导免疫缺陷可能在先天性CMV感染的发病机制中起作用。
