先天性巨细胞病毒感染婴儿中巨细胞病毒特异性T细胞免疫和病毒复制的纵向动力学
Longitudinal Kinetics of Cytomegalovirus-Specific T-Cell Immunity and Viral Replication in Infants With Congenital Cytomegalovirus Infection.
作者信息
Chen Sharon F, Holmes Tyson H, Slifer Teri, Ramachandran Vasavi, Mackey Sally, Hebson Cathleen, Arvin Ann M, Lewis David B, Dekker Cornelia L
机构信息
Department of Pediatrics.
Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California.
出版信息
J Pediatric Infect Dis Soc. 2016 Mar;5(1):14-20. doi: 10.1093/jpids/piu089. Epub 2014 Sep 11.
BACKGROUND
Congenital cytomegalovirus (CMV) is reported to affect up to 1% of all live births in the United States. T-cell immunity may be important for controlling CMV replication in congenital CMV-infected infants. We describe the natural history of CMV-specific T-cell evolution and CMV replication in infants with congenital CMV infection.
METHODS
Cytomegalovirus viral load, CMV urine culture, and CMV-specific CD4 and CD8 T-cell responses were assessed in a prospective longitudinal cohort of 51 infants with congenital CMV infection who were observed from birth to 3 years of age.
RESULTS
We found a kinetic pattern of decreasing urinary CMV replication and increasing CMV-specific CD4 and CD8 T-cell responses during the first 3 years of life. We also found higher CMV-specific CD8 T-cell responses were associated with subsequent reduction of urine CMV viral load.
CONCLUSION
For infants with congenital CMV infection, our data suggest an age-related maturation of both CMV-specific CD4 and CD8 T-cell immunity that is associated with an age-related decline in urinary CMV replication.
背景
据报道，先天性巨细胞病毒（CMV）在美国所有活产婴儿中的感染率高达1%。T细胞免疫对于控制先天性CMV感染婴儿体内的CMV复制可能很重要。我们描述了先天性CMV感染婴儿中CMV特异性T细胞演变和CMV复制的自然史。
方法
对51例先天性CMV感染婴儿进行前瞻性纵向队列研究，从出生至3岁观察其巨细胞病毒病毒载量、CMV尿培养以及CMV特异性CD4和CD8 T细胞反应。
结果
我们发现，在生命的前3年中，尿中CMV复制减少，CMV特异性CD4和CD8 T细胞反应增加，呈现出一种动态变化模式。我们还发现，较高的CMV特异性CD8 T细胞反应与随后尿中CMV病毒载量的降低有关。
结论
对于先天性CMV感染的婴儿，我们的数据表明，CMV特异性CD4和CD8 T细胞免疫与年龄相关的成熟，这与尿中CMV复制随年龄的下降有关。
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